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Invitrogen
PRKD2 Polyclonal Antibody
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FIGURE: 1 / 4
PRKD2 Antibody (PA5-102887) in ICC/IF
Immunofluorescent analysis of PRKD2 in HepG2 cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and PRKD2 polyclonal antibody (Product # PA5-102887) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-102887
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PRKD2(Accession Q9BZL6), corresponding to amino acid residues G10-L60.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PRKD2.
Target Information
PRKD2 (PKD2) is a member of the protein kinase D serine/threonine protein kinase family. PRKD2 is a component in the signal transduction pathway induced by phorbol esters and the CCK b gastrin receptor. It exhibits the strongest homology to the serine threonine protein kinases PKD/PKC and PKCnu, particularly in the duplex zinc finger-like cysteine-rich motif, in the pleckstrin homology domain and in the protein kinase domain. In contrast, it shows only a low degree of sequence similarity to other members of the PKC family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: nPKC-D2; PKD2; Serine/threonine-protein kinase D2; unnamed protein product
Gene Aliases: AI325941; HSPC187; nPKC-D2; PKD2; PRKD2
UniProt ID: (Human) Q9BZL6, (Mouse) Q8BZ03
Entrez Gene ID: (Human) 25865, (Mouse) 101540
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
protein kinase C binding
protein binding
ATP binding
zinc ion binding
kinase activity
transferase activity
metal ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
angiogenesis
positive regulation of endothelial cell proliferation
adaptive immune response
immune system process
protein phosphorylation
cell adhesion
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of endothelial cell migration
sphingolipid biosynthetic process
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of interleukin-2 production
positive regulation of interleukin-8 production
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
positive regulation of blood vessel endothelial cell migration
positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of transcription from RNA polymerase II promoter
vascular endothelial growth factor receptor signaling pathway
T cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
endothelial tube morphogenesis
regulation of T cell apoptotic process
positive regulation of ERK1 and ERK2 cascade
positive regulation of DNA biosynthetic process
positive regulation of endothelial cell chemotaxis
cell death
phosphorylation
peptidyl-serine phosphorylation
positive regulation of CREB transcription factor activity
positive regulation of peptidyl-serine phosphorylation
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
protein autophosphorylation
protein kinase D signaling
mitophagy in response to mitochondrial depolarization
positive regulation of histone deacetylase activity
positive regulation of intracellular signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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