Search
Proteintech
PRKG1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
21646-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PRKG1 Fusion Protein Ag16333 (1-178 aa encoded by BC127090)
Conjugate
Form
Liquid
Concentration
0.51 mg/mL
Amount
76.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGTLRDLQY ALQEKIEELR QRDALIDELE LELDQKDELI QKLQNELDKY RSVIRPATQQ AQKQSASTLQ GEPRTKRQAI SAEPTAFDIQ DLSHVTLPFY PKSPQSKDLI KEAILDNDFM KNLELSQIQE IVDCMYPVEY GKDSCIIKEG DVGSLVYVME DGKVEVTKEG VKLCTMGPG (1-178 aa encoded by BC127090 )
Target Information
PRKG1 is a cGMP-dependent serine/threonine kinase which has an important role in the relaxation of vascular smooth muscle and the inhibition of platelet aggregation. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cGK 1; cGK cGK cGKI; cGK cGK1; cGK1; cGKI; cGMP dependent protein kinase type 1; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; OTTHUMP00000019618; protein kinase, cGMP-dependent, regulatory, type I, beta; protein kinase, cGMP-dependent, type I; RP11-346D6.1; unnamed protein product
Gene Aliases: AAT8; AW125416; cGK; cGK 1; cGK1; CGKI; cGKI-alpha; cGKI-BETA; Gm19690; PKG; PKG1; Pkgi; PRKG1; PRKG1B; PRKGR1A; PRKGR1B
UniProt ID: (Human) Q13976, (Mouse) P0C605
Entrez Gene ID: (Human) 5592, (Mouse) 19091, (Rat) 54286
nucleotide binding
catalytic activity
protein kinase activity
protein serine/threonine kinase activity
cGMP-dependent protein kinase activity
calcium channel regulator activity
protein binding
ATP binding
kinase activity
transferase activity
cGMP binding
identical protein binding
mitogen-activated protein kinase p38 binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
protein homodimerization activity
non-receptor serine/threonine protein kinase
neuron migration
protein phosphorylation
signal transduction
positive regulation of cytosolic calcium ion concentration
spermatid development
heart development
negative regulation of inositol phosphate biosynthetic process
negative regulation of glutamate secretion
negative regulation of smooth muscle cell migration
dendrite development
cGMP-mediated signaling
cerebellum development
actin cytoskeleton organization
forebrain development
vasodilation
positive regulation of circadian rhythm
regulation of GTPase activity
regulation of vascular permeability
negative regulation of smooth muscle contraction
collateral sprouting
relaxation of vascular smooth muscle
cell growth involved in cardiac muscle cell development
negative regulation of platelet aggregation
bone growth
negative regulation of vascular smooth muscle cell proliferation
negative regulation of vascular associated smooth muscle cell migration
regulation of testosterone biosynthetic process
metabolic process
phosphorylation
negative regulation of heart contraction
positive regulation of vasodilation
mitophagy in response to mitochondrial depolarization
positive regulation of large conductance calcium-activated potassium channel activity
brain development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support