Suggested positive control: HeLa, NIH-3T3, Hela whole cell extract, antigen standard for PRMT5 (transient overexpression lysate).
PRMT5 (protein arginine N-methyltransferase 5) is an arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. PRMT5 specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3; such methylation is required for the assembly and biogenesis of snRNP core particles.
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Protein Aliases: 72 kDa ICln-binding protein; EC 184.108.40.206; Histone-arginine N-methyltransferase PRMT5; HMT1 hnRNP methyltransferase-like 5; Jak-binding protein 1; PRMT5; Protein arginine N-methyltransferase 5; Protein arginine N-methyltransferase 5, N-terminally processed; Shk1 kinase-binding protein 1 homolog; SKB1 homolog
Gene Aliases: HRMT1L5; IBP72; JBP1; PRMT5; SKB1; SKB1Hs
Molecular Function: protein modifying enzyme