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Product Details
PA5-69069
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of human PRMT6
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2690194
Product Specific Information
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rat: 100%
Target Information
Protein arginine N-methyltransferase 6 (PRMT6) PRMT6 demonstrates type I PRMT activity, capable of forming both omega-N monomethylarginine and asymmetric dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. cts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ10559; FLJ51477; HMT1 hnRNP methyltransferase-like 6; PRMT-6; protein arginine N-methyltransferase 6
Gene Aliases: Hrmt1l6
Entrez Gene ID: (Rat) 295384
molecular_function
chromatin binding
histone-arginine N-methyltransferase activity
protein-arginine N-methyltransferase activity
protein-arginine omega-N monomethyltransferase activity
protein-arginine omega-N asymmetric methyltransferase activity
histone methyltransferase activity
histone binding
histone methyltransferase activity (H4-R3 specific)
histone methyltransferase activity (H3-R2 specific)
histone methyltransferase activity (H2A-R3 specific)
protein modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
biological_process
cell growth
histone methylation
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
histone arginine methylation
histone H3-R2 methylation
histone H4-R3 methylation
negative regulation of transcription, DNA-templated
cellular senescence
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