Proteintech

PRMT8 Polyclonal Antibody

2 References
View all (6) PRMT8 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

12557-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
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Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PRMT8 Fusion Protein Ag3166 (95-394 aa encoded by BC022458)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody recognizes all of isoforms of PRMT8.

Immunogen sequence: RTLTYRNSM YHNKHVFKDK VVLDVGSGTG ILSMFAAKAG AKKVFGIECS SISDYSQKII KANHLDNIIT IFKGKVEEVE LPVEKVDIII SEWMGYCLFY ESMLNTVIFA RDKWLKPGGL MFPDRAALYV VAIEDRQYKD FKIHWWENVY GFDMTCIRDV AMKEPLVDIV DPKQVVTNAC LIKEVDIYTV KTEELSFTSA FCLQIQRNDY VHALVTYFNI EFTKCHKKMG FSTAPDAPYT HWKQTVFYLE DYLTVRRGEE IYGTISMKPN AKNVRDLDFT VDLDFKGQLC ETSVSNDYKM R (95-394 aa encoded by BC022458)

Target Information

Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: arginine methyltransferase 8; heterogeneous nuclear ribonucleoprotein methyltransferase-like 4; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4; HMT1 hnRNP methyltransferase-like 3; protein arginine N-methyltransferase 4; Protein arginine N-methyltransferase 8

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Gene Aliases: HRMT1L3; HRMT1L4; PRMT8

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UniProt ID: (Human) Q9NR22, (Mouse) Q6PAK3

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Entrez Gene ID: (Human) 56341, (Mouse) 381813, (Rat) 688502

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Function(s)
protein binding histone-arginine N-methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity protein-arginine omega-N monomethyltransferase activity protein-arginine omega-N asymmetric methyltransferase activity identical protein binding protein homodimerization activity protein heterodimerization activity rRNA (adenine-N6,N6-)-dimethyltransferase activity protein C-terminal carboxyl O-methyltransferase activity tRNA (guanine-N2-)-methyltransferase activity methyltransferase activity C-methyltransferase activity N-methyltransferase activity O-methyltransferase activity S-methyltransferase activity RNA methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity protein methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity rRNA methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (adenine-N6-)-methyltransferase activity DNA-methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity selenocysteine methyltransferase activity arginine N-methyltransferase activity protein-arginine N-methyltransferase activity lysine N-methyltransferase activity protein-lysine N-methyltransferase activity tRNA (uracil) methyltransferase activity tRNA (guanine) methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity rRNA (adenine) methyltransferase activity rRNA (cytosine) methyltransferase activity rRNA (guanine) methyltransferase activity rRNA (uridine) methyltransferase activity transferase activity protein C-terminal leucine carboxyl O-methyltransferase activity 1-phenanthrol methyltransferase activity protein-arginine N5-methyltransferase activity methylarsonite methyltransferase activity dimethylarsinite methyltransferase activity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 1-hydroxypyrene methyltransferase activity 1-hydroxy-6-methoxypyrene methyltransferase activity demethylmenaquinone methyltransferase activity cobalt-precorrin-6B C5-methyltransferase activity cobalt-precorrin-7 C15-methyltransferase activity cobalt-precorrin-5B C1-methyltransferase activity cobalt-precorrin-3 C17-methyltransferase activity dimethylamine methyltransferase activity hydroxyneurosporene-O-methyltransferase activity tRNA (adenine-57, 58-N(1)-) methyltransferase activity methylamine-specific methylcobalamin:coenzyme M methyltransferase activity trimethylamine methyltransferase activity methanol-specific methylcobalamin:coenzyme M methyltransferase activity monomethylamine methyltransferase activity histone methyltransferase activity (H4-R3 specific) P-methyltransferase activity Se-methyltransferase activity 2-phytyl-1,4-naphthoquinone methyltransferase activity tRNA (uracil-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity phosphomethylethanolamine N-methyltransferase activity tRNA (cytosine-3-)-methyltransferase activity rRNA (cytosine-2'-O-)-methyltransferase activity rRNA (cytosine-N4-)-methyltransferase activity trihydroxyferuloyl spermidine O-methyltransferase activity molecular_function protein modifying enzyme
Process(es)
regulation of transcription, DNA-templated histone methylation peptidyl-arginine methylation peptidyl-arginine methylation, to asymmetrical-dimethyl arginine histone arginine methylation regulation of protein binding protein methylation methylation histone H4-R3 methylation biological_process
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