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Proteintech
PROC Polyclonal Antibody
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Product Details
25382-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PROC Fusion Protein Ag11328 (113-461 aa encoded by BC034377)
Conjugate
Form
Liquid
Concentration
0.34 mg/mL
Amount
51 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DGIGSFSCD CRSGWEGRFC QREVSFLNCS LDNGGCTHYC LEEVGWRRCS CAPGYKLGDD LLQCHPAVKF PCGRPWKRME KKRSHLKRDT EDQEDQVDPR LIDGKMTRRG DSPWQVVLLD SKKKLACGAV LIHPSWVLTA AHCMDESKKL LVRLGEYDLR RWEKWELDLD IKEVFVHPNY SKSTTDNDIA LLHLAQPATL SQTIVPICLP DSGLAERELN QAGQETLVTG WGYHSSREKE AKRNRTFVLN FIKIPVVPHN ECSEVMSNMV SENMLCAGIL GDRQDACEGD SGGPMVASFH GTWFLVGLVS WGEGCGLLHN YGVYTKVSRY LDWIHGHIRD KEAPQKSWAP (113-461 aa encoded by BC034377)
Target Information
Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3 ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3 µg/mL. Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activated protein C; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; coagulation factor XIV; EDQVDPRLIDGK; inactivator of coagulation factors Va, VIII; prepro-protein C; Protein C-Nagoya; type I protein C; unnamed protein product; Vitamin K-dependent protein C
Gene Aliases: APC; PC; PROC; PROC1; THPH3; THPH4
UniProt ID: (Human) P04070, (Mouse) P33587
Entrez Gene ID: (Human) 5624, (Mouse) 19123
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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