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Product Details
PA5-142524
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-HPLTRKNNFGNGRQE.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933171
Product Specific Information
Additional Information: This antibody is expected to recognize isoform a (NP_001119600.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Preliminary analysis showed no signal in Western Blot.
Target Information
Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the suprachiasmatic nucleus (SCN) with receptors located in the critical autonomic control centers of the brain. It has a depolarizing effect on neurons expressing the receptor. PK2 is predominantly controlled by the endogenous circadian clock, but light also plays a modulatory role. PK2 functions as a critical SCN output molecule responsible for circadian locomotor rhythms. PK2 expression is high during the day, and responsive to nocturnal light pulses. PK2 also functions as a chemoattractant for subventricular zone-derived neuronal progenitors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PK2; Prokineticin-2; Protein Bv8 homolog
Gene Aliases: BV8; HH4; KAL4; MIT1; PK2; PROK2
UniProt ID: (Human) Q9HC23
Entrez Gene ID: (Human) 60675
activation of MAPK activity
angiogenesis
chemotaxis
inflammatory response
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
spermatogenesis
circadian rhythm
cell proliferation
positive regulation of cell proliferation
sensory perception of pain
negative regulation of apoptotic process
regulation of angiogenesis
positive regulation of smooth muscle contraction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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