Positive Samples: Mouse brain
PROP1 encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone.
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Protein Aliases: Ames dwarf; Homeobox protein prophet of Pit-1; pituitary specific homeodomain factor; Pituitary-specific homeodomain factor; PROP-1; prophet of Pit-1; prophet of Pit1, paired-like homeodomain transcription factor
Gene Aliases: CPHD2; df; PROP-1; PROP1
Molecular Function: homeodomain transcription factor