Immunogen sequence: MDINKPGPLF KPENGLLETK VYFAGFPRKV ESELIKPINP RLDGCIRSWN LMKQGASGIK EIIQEKQNKH CLVTVEKGSY YPGSGIAQFH IDYNNVSSAE GWHVNVTLNI RPSTGTGVML ALVSGNNTVP FAVSLVDSTS EKSQDILLSV ENTVIYRIQA LSLCSDQQSH LEFRVNRNNL ELSTPLKIET ISHEDLQRQL AVLDKAMKAK VATYLGGLPD VPFSATPVNA FYNGCMEVNI NGVQLDLDEA ISKHNDIRAH SCPSVWKKTK NS; Positive Samples: LO2, HeLa, 293T, Mouse liver, Mouse kidney, Rat liver, Rat kidney
Protein S is a vitamin K-dependent, potent neutral anticoagulant plasma glycoprotein. Protein S has a molecular weight of approximately 70 kDa and consists of a single polypeptide chain. The concentration of protein S in human plasma is 25 µg/mL, with a half-life of approximately two days. About 40% of Protein S in plasma is in a free form, whereas 60% is complexed with C4b-binding Protein (C4BP). Only the free Protein S functions as a cofactor to antigen presenting cells (APC) in the APC-dependent degradation of Factor Va and Factor VIIIa.
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Protein Aliases: protein Sa; vitamin K-dependent plasma protein S; Vitamin K-dependent protein S
Gene Aliases: AW214361; PROS; PROS1; PS21; PS22; PS23; PS24; PS25; PSA; THPH5; THPH6