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Invitrogen
PRP8 Polyclonal Antibody
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Product Details
PA5-96497
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PRPF8 (NP_0064363)
Conjugate
Form
Liquid
Concentration
0.99 mg/mL
Amount
99 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAGVFPYRGP GNPVPGPLAP LPDYMSEEKL QEKARKWQQL QAKRYAEKRK FGFVDAQKED MPPEHVRKII RDHGDMTNRK FRHDKRVYLG ALKYMPHAVL; Positive Samples: HeLa, Jurkat; Cellular Location: Nucleus speckle
Target Information
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 220 kDa U5 snRNP-specific protein; apoptosis-regulated protein 1; apoptosis-regulated protein 2; ARP1; ARP2; H PRPC8; p220; Pre-mRNA-processing-splicing factor 8; precursor mRNA processing protein; PRP8 homolog; PRP8 pre-mRNA processing factor 8 homolog; spl; Splicing factor Prp8; U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p; unnamed protein product
Gene Aliases: AU019467; D11Bwg0410e; DBF3/PRP8; HPRP8; PRP8; PRPC8; PRPF8; RP13; Sfprp8l; SNRNP220
UniProt ID: (Human) Q6P2Q9, (Mouse) Q8K001
Entrez Gene ID: (Human) 10594, (Rat) 287530, (Mouse) 192159
RNA binding
protein binding
peptidase activity
U6 snRNA binding
U1 snRNA binding
U2 snRNA binding
U5 snRNA binding
K63-linked polyubiquitin binding
pre-mRNA intronic binding
metal-dependent deubiquitinase activity
molecular_function
poly(A) RNA binding
second spliceosomal transesterification activity
nucleic acid binding
RNA splicing factor
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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