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Invitrogen
PRPF18 Polyclonal Antibody
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Product Details
PA5-58031
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PRPF18. Recombinant protein control fragment (Product #RP-97130).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SNPVLELELA EEKLPMTLSR QEVIRRLRER GEPIRLFGET DYDAFQRLRK IEILTPEVNK GLRNDLKAAL DKIDQQYLNE IVG
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 99%.
Target Information
PRPF18 (pre-mRNA-splicing factor 18), also known as HPRP18, is a 342 amino acid protein that localizes to nuclear speckles and plays a role in the second step of pre-mRNA splicing. A member of the PRP18 family, PRPF18 contains seven WD repeats and exists as two alternatively spliced isoforms which are encoded by a gene located on human chromosome 10p13. Chromosome 10 contains over 800 genes and 135 million nucleotides. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Other chromosome 10 associated disorders include Cockayne syndrome, tetrahydrobiopterin deficiency and trisomy 10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hPRP18; HPRP18 homolog; Potassium channel regulatory factor; Pre-mRNA-splicing factor 18; PRP18 homolog; PRP18 pre-mRNA processing factor 18 homolog; PRP18 pre-mRNA processing factor 18 homolog(PRPF18)
Gene Aliases: 2810441A10Rik; HPRP18; Kcrf; Pprf18; PRP18; PRPF18
UniProt ID: (Human) Q99633, (Rat) Q9JKB8, (Mouse) Q8BM39
Entrez Gene ID: (Human) 8559, (Rat) 171552, (Mouse) 67229
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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