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Invitrogen
PRPF39 Polyclonal Antibody
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Product Details
PA5-101773
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PRPF39(Accession Q86UA1), corresponding to amino acid residues T630-T669.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PRPF39.
Target Information
The PRPF39 gene plays a critical role as a splicing factor involved in alternative splicing regulation. In humans, it is homologous to the yeast Prp39 and Prp42 paralogs, forming a homodimer that interacts with the carboxy-terminal domain (CTD) of U1C, a parallel mechanism observed in the yeast Prp39/Prp42 heterodimer. Recent studies have highlighted its impact on splicing efficiency through knockdown experiments in HEK293 cells, which revealed significant changes in the expression of many genes, underscoring its importance in splicing adaptability according to cell type-specific needs. Additionally, PRPF39 is found to be highly expressed in Acute Lymphoblastic Leukemia (ALL), with research suggesting that targeting PRPF39 for degradation could contribute to the treatment of ALL. Phylogenetic analyses indicate a coevolution of PRPF39 expression with molecular components like shortened U1 snRNA, reflecting the splicing complexity across different species. The gene is also involved in the regulation of distant genes which are relevant to cellular responses, such as those involved in cisplatin response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: flj11128; flj20666; flj45460; mgc149842; mgc149843; Pre-mRNA-processing factor 39; PRP39 homolog; PRP39 pre-mRNA processing factor 39 homolog; unnamed protein product; v-src suppressed transcript 1
Gene Aliases: PRPF39; Srcs1
UniProt ID: (Human) Q86UA1
Entrez Gene ID: (Human) 55015, (Rat) 314171, (Mouse) 328110
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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