Immunogen sequence: GSLENTLGQG LKNGMKYYRD TDTPGRCFMK KTIDMLQIEF KCCGNNGFRD WFEIQWISNR YLDFSSKEVK DRIKSNVDGR YLVDGVPFSC CNPSSPRPCI QYQITNNSAH YSYDHQTEEL NLWVR
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 50%.
Peripherin-2 (PRPH2), also known as retinal degeneration slow protein (RDS), is a photoreceptor-specific tetraspanin protein implicated in outer segment disk morphogenesis. It may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Mutations in peripherin-2 are responsible for various retinal degenerative diseases including autosomal dominant retinitis pigmentosa (ADRP).
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Protein Aliases: peripherin 2 (retinal degeneration, slow); peripherin 2, homolog of mouse; peripherin, photoreceptor type; Peripherin-2; Retinal degeneration slow protein; retinal peripherin; Tetraspanin-22; Tspan-22
Gene Aliases: AOFMD; AVMD; CACD2; DS; MDBS1; PRPH; PRPH2; rd2; RDS; RP7; TSPAN22
UniProt ID: (Human) P23942
Entrez Gene ID: (Human) 5961