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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.2-1 µg/mL | - |
Immunocytochemistry (ICC/IF) |
1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide directed towards the N-terminal of human TP53RK |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS with 2% sucrose |
Contains |
0.09% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2605905 |
Peptide sequence: MAAARATTPA DGEEPAPEAE ALAAARERSS RFLSGLELVK QGAEARVFRG
Sequence homology: Human: 100%
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Atypical serine/threonine protein kinase TP53RK; EKC/KEOPS complex subunit TP53RK; Nori-2; p53-related protein kinase; TP53-regulating kinase
Gene Aliases: BUD32; C20orf64; dJ101A2; Nori-2; Nori-2p; PRPK; TP53RK; Trp53rk
UniProt ID: (Human) Q96S44
Entrez Gene ID: (Human) 112858, (Rat) 362272
Molecular Function:
hydrolase
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