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Invitrogen
PRPS2 Polyclonal Antibody
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Product Details
PA5-42007
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
C. elegans,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human PRPS2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: VSPDAGGAKR VTSIADRLNV EFALIHKERK KANEVDRMVL VGDVKDRVAI
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Target Information
The Phosphoribosyl Pyrophosphate Synthetase 2 (PRPS2) gene plays a critical role in cellular metabolism by encoding an enzyme that conducts a key reaction linking central carbon metabolism and nucleotide production, essential for various biological functions. Structurally, PRPS2 shares a high sequence identity with PRPS1, making it less sensitive to allosteric inhibition and particularly significant in certain oncology contexts due to its upregulation at the translational level in some cancers. The enzyme encoded by PRPS2 is pivotal in coupling protein and nucleotide biosynthesis, aided by a unique cis-regulatory element in its 5' UTR, which is influenced by oncogenic pathways. This gene manifests a tissue-specific expression profile, predominantly in proliferative tissues such as the thymus, lung, and small intestine, highlighting its significance in cell growth and proliferation. The evolutionary origins of PRPS2, along with its functional diversification into multiple PRPS genes in eukaryotes, underscore its indispensable role in cellular physiology and pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Phosphoribosyl pyrophosphate synthase II; PPRibP; PPRibP synthetase; PRS-II; ribose-phosphate diphosphokinase 2; Ribose-phosphate pyrophosphokinase 2; testicular secretory protein Li 41
Gene Aliases: PRPS2; PRSII
UniProt ID: (Human) P11908
Entrez Gene ID: (Human) 5634
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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