Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
A suggested positive control is NIH-3T3 cell lysate.
PA5-21129 can be used with blocking peptide PEP-1243.
Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2). PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2. Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Proline-rich protein 5-like; Protein observed with Rictor-2; Protor-2
Gene Aliases: 2600010E01Rik; 4833411O04Rik; Protor-2; PROTOR2; PRR5L
UniProt ID: (Human) Q6MZQ0, (Mouse) A2AVJ5
Entrez Gene ID: (Human) 79899, (Mouse) 72446
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support