A recommended positive control is HeLa cell lysate.
At least two isoforms of PRRX1 are known to exist; this antibody will detect both isoforms.
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns.
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Protein Aliases: Homeobox protein K-2; Homeobox protein mHox; Homeobox protein PHOX1; paired mesoderm homeobox 1; paired mesoderm homeobox 1 isoform pmx-1b; Paired mesoderm homeobox protein 1; Paired related homeobox 1; Paired-related homeobox protein 1; PHOX1; PRX-1; PRX1; rHox
Gene Aliases: A230024N07Rik; AA755424; AGOTC; AI385634; AI843499; K-2; mHox; PHOX1; Pmx; PMX1; PRRX1; PRX-1; PRX1