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Invitrogen
PRRX1 Polyclonal Antibody
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Product Details
PA5-75553
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 100-145 of Human PRRX1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. PRX1 (paired related homeobox 1), also known as PRRX1, PMX1 or PHOX1, is a 245 amino acid protein that contains one OAR domain and one homeobox DNA-binding domain and belongs to the paired homeobox family. Localized to the nucleus, PRX1 functions as a transcriptional co-activator that enhances the DNA-binding activity of serum response factor (SRF), thereby mediating the induction of SRF-dependent gene expression by growth and differentiation factors. Additionally, PRX1 regulates the transcriptional activities of creatine kinase-M (muscle), thereby playing a role in the establishment of mesodermal muscle types. PRX1 exists as two alternatively spliced isoforms, designated PMX1-A and PMX1-B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Homeobox protein K-2; homeobox protein mHox; Homeobox protein PHOX1; MHox; Muscle homeobox protein; paired mesoderm homeobox 1; Paired mesoderm homeobox protein 1; Paired-related homeobox protein 1; PRX-1; rHox
Gene Aliases: A230024N07Rik; AA755424; AGOTC; AI385634; AI843499; K-2; mHox; PHOX1; Pmx; PMX1; PRRX1; PRX-1; PRX1
UniProt ID: (Human) P54821, (Mouse) P63013, (Rat) P63014
Entrez Gene ID: (Human) 5396, (Mouse) 18933, (Rat) 266813
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
obsolete general RNA polymerase II transcription factor activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
HMG box domain binding
RNA polymerase II transcription coactivator activity
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
positive regulation of mesenchymal cell proliferation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
embryonic limb morphogenesis
inner ear morphogenesis
middle ear morphogenesis
positive regulation of smoothened signaling pathway
positive regulation of transcription from RNA polymerase II promoter
neuron fate determination
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
artery morphogenesis
cartilage development
palate development
regulation of neuron projection regeneration
neuronal stem cell population maintenance
regulation of transcription from RNA polymerase II promoter
smoothened signaling pathway
mesenchymal cell proliferation
stem cell proliferation
positive regulation of stem cell proliferation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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