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Invitrogen
PRRX2 Polyclonal Antibody
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FIGURE: 1 / 4
PRRX2 Antibody (PA5-103995) in IHC (P)
Immunohistochemistry analysis of PRRX2 in human pancreatic cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PRRX2 polyclonal antibody (Product # PA5-103995) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103995
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PRRX2(Accession Q99811), corresponding to amino acid residues A65-Q115.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PRRX2.
Target Information
The paired-class homeobox genes PRX1 and PRX2 are necessary for craniofacial and limb development and are expressed in similar patterns in the cranial mesenchyme, limb buds, axial mesoderm and branchial arches. These proteins exhibit different patterns of expression, however, in heart and brain tissue. Specifically, PRX1 is expressed in the endocardial cusions, semilunar and atrioventricular valves, whereas PRX2 is initially expressed in a diffuse myocardial pattern and is later expressed in the ventricular septum. Furthermore, PRX2 is never expressed in the brain, whereas PRX1 is expressed in the ventral hypothalamus and in the telencephalon. Murine mutants lacking PRX1 function demonstrate skeletal defects in the skull, limbs, and vertebral column. Mice lacking functional PRX2 alone do not demonstrate skeletal abnormalities, however, PRX1/PRX2 double mutants demonstrate novel abnormalities that are not visualized with the PRX1-deficient mice. Transcripts of neither PRX1 nor PRX2 are detected in normal adult rat pulmonary arteries, however vascular disease induces PRX gene expression wherein they co-localize to sites of Tenascin-C expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box of paired rule; Homeobox protein S8; MGC19843; Paired mesoderm homeobox protein 2; paired-like homeodomain protein PRX2; Paired-related homeobox protein 2; PRX-2; surface antigen, homeo box of paired rule; testicular tissue protein Li 148; testicular tissue protein Li 160
Gene Aliases: PMX2; PRRX2; PRX2; S8
UniProt ID: (Human) Q99811, (Mouse) Q06348
Entrez Gene ID: (Human) 51450, (Mouse) 20204, (Rat) 113931
positive regulation of mesenchymal cell proliferation
regulation of transcription, DNA-templated
multicellular organism development
embryonic limb morphogenesis
inner ear morphogenesis
middle ear morphogenesis
positive regulation of smoothened signaling pathway
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
artery morphogenesis
cartilage development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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