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Proteintech
PRSS2 Polyclonal Antibody
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Product Details
15005-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PRSS2 Fusion Protein Ag6461 (1-247 aa encoded by BC030260)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MNLLLILTF VAAAVAAPFD DDDKIVGGYI CEENSVPYQV SLNSGYHFCG GSLISEQWVV SAGHCYKSRI QVRLGEHNIE VLEGNEQFIN AAKIIRHPKY NSRTLDNDIL LIKLSSPAVI NSRVSAISLP TAPPAAGTES LISGWGNTLS SGADYPDELQ CLDAPVLSQA ECEASYPGKI TNNMFCVGFL EGGKDSCQGD SGGPVVSNGE LQGIVSWGYG CAQKNRPGVY TKVYNYVDWI (1-247 aa encoded by BC030260)
Target Information
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Anionic trypsin II; Anionic trypsin-2; Anionic trypsinogen; EC 3.4.21; EC 3.4.21.4; MGC111183; MGC120174; MGC120175; pancreatic trypsin 2; pancreatic trypsin II; Pretrypsinogen II; protease serine 2 preproprotein; protease, serine, 2; protease, serine, 2 (trypsin 2); Serine protease 2; trypsin 2; Trypsin II; trypsin Trypsin II; Trypsin-2; trypsinogen 2; trypsinogen 20
Gene Aliases: PRSS2; Ptryss2; Ta; Tesp4; TRY2; TRY8; TRYP; TRYP2
UniProt ID: (Human) P07478, (Mouse) P07146, (Rat) P00763
Entrez Gene ID: (Human) 5645, (Mouse) 22072, (Rat) 25052
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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