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      PRTFDC1 Polyclonal Antibody

      See 3 other PRTFDC1 antibodies ›
      PRTFDC1 Polyclonal Antibody for Western Blot

      Catalog#: PA5-20593 Invitrogen

      Catalog # Size Price (USD) Qty Datasheet
      PA5-20593 100 ug
      349.00
      Please enter a quantity in the range of 1 to 199.
      Suggested Secondary Antibodies

      Anti-Rabbit Secondary Antibodies (264)
      Alexa Fluor® Anti-Rabbit Secondary Antibodies (69)
      HRP Anti-Rabbit Secondary Antibodies (30)

      Product Details

      Bioinformatics

      Documents
      Details
      Tested species reactivity Human, Rat
      Host / Isotype Rabbit / IgG
      Class Polyclonal
      Type Antibody
      Immunogen A 14 amino acid peptide from near the center of human PRTFDC1.
      Conjugate Unconjugated
      Form Liquid
      Concentration 1 mg/ml
      Purification Antigen affinity chromatography
      Storage buffer PBS
      Contains 0.02% sodium azide
      Storage Conditions Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
      Tested Applications Dilution *
      Western Blot (WB) 1 µg/ml

      * Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.

      Product Specific Information

      A suggested positive control is human brain tissue lysate.

      PA5-20593 can be used with blocking peptide PEP-0713.

      Background/Target Information

      Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      Documents

      Material safety data sheets (MSDS)

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