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Abnova
PRTN3 Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 2
PRTN3 Antibody (H00005657-D01P) in WB
Western Blot analysis of PRTN3 expression in transfected 293T cell line (H00005657-T01) by PRTN3 MaxPab polyclonal antibody.
Lane 1: PRTN3 transfected lysate(27.80 KDa).
Lane 2: Non-transfected lysate.
Lane 1: PRTN3 transfected lysate(27.80 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00005657-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PRTN3 (AAH96184.1, 1 a.a. approximately 256 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MAHRPPSPAL ASVLLALLLS GAARAAEIVG GHEAQPHSRP YMASLQMRGN PGSHFCGGTL IHPSFVLTAA HCLRDIPQRL VNVVLGAHNV RTQEPTQQHF SVAQVFLNNY DAENKLNDIL LIQLSSPANL SASVATVQLP QQDQPVPHGT QCLAMGWGRV GAHDPPAQVL QELNVTVVTF FCRPHNICTF VPRRKAGICF GDSGGPLICD GIIQGIDSFV IWGCATRLFP DFFTRVALYV DWIRSTLRRV EAKGRP
Target Information
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AGP7; azurophil granule protein 7; C-ANCA antigen; Leukocyte proteinase 3; Myeloblastin; Neutrophil proteinase 4; NP-4; P29; PR-3; Proteinase 3; serine proteinase, neutrophil; unnamed protein product; Wegener autoantigen; Wegener granulomatosis autoantigen
Gene Aliases: ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; mPR3; NP-4; NP4; P29; PR-3; PR3; PRTN3
UniProt ID: (Human) P24158, (Mouse) Q61096
Entrez Gene ID: (Human) 5657, (Mouse) 19152
proteolysis
membrane protein ectodomain proteolysis
positive regulation of cell proliferation
antimicrobial humoral response
collagen catabolic process
positive regulation of GTPase activity
cell-cell junction maintenance
negative regulation of phagocytosis
neutrophil extravasation
mature conventional dendritic cell differentiation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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