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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat, Mouse, Human, Chicken|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH-conjugated synthethic peptide derived from the C-terminal region of human PSD-95.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||0.1-1.0 ug/ml|
|Immunofluorescence (IF)||0.5-1.0 ug/ml|
|Immunoprecipitation (IP)||5 ug|
|Western Blot (WB)||1.0 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a member of the membrane-associated guanylate kinase family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.
51-6900 was used in immunohistochemistry - free floating to assess the Src family kinase inhibitor, AZD0530, for treatment of Alzheimer's disease
|Kaufman AC,Salazar SV,Haas LT,Yang J,Kostylev MA,Jeng AT,Robinson SA,Gunther EC,van Dyck CH,Nygaard HB,Strittmatter SM||Annals of neurology (77:953)||2015|
Expression of the postsynaptic scaffold PSD-95 and development of synaptic physiology during giant terminal formation in the auditory brainstem of the chicken.
51-6900 was used in western blot to study the expression of PSD-95 during the transition from bouton-to-endbulb synapses.
|Goyer D,Fensky L,Hilverling AM,Kurth S,Kuenzel T||The European journal of neuroscience (41:1416)||2015|
REDD1 is essential for stress-induced synaptic loss and depressive behavior.
51-6900 was used in western blot to identify REDD as a mediator neuronal atrophy and depressive behavior caused by chronic stress exposure.
|Ota KT,Liu RJ,Voleti B,Maldonado-Aviles JG,Duric V,Iwata M,Dutheil S,Duman C,Boikess S,Lewis DA,Stockmeier CA,DiLeone RJ,Rex C,Aghajanian GK,Duman RS||Nature medicine (20:531)||2014|
|Mouse||Not Cited||Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling.||Renvoisé B,Stadler J,Singh R,Bakowska JC,Blackstone C||Human molecular genetics (21:3604)||2012|
Rapid neurogenesis through transcriptional activation in human stem cells.
51-6900 was used in immunocytochemistry to describe a method to rapidly generate neurons from human-induced pluripotent stem cells to elucidate the underlying regulatory programs
|Busskamp V,Lewis NE,Guye P,Ng AH,Shipman SL,Byrne SM,Sanjana NE,Murn J,Li Y,Li S,Stadler M,Weiss R,Church GM||Molecular systems biology (10:null)||2014|
Process-based expansion and neural differentiation of human pluripotent stem cells for transplantation and disease modeling.
51-6900 was used in immunocytochemistry to evaluate a cell culture system for long-term passaging of human pluripotent stem cells
|Stover AE,Brick DJ,Nethercott HE,Banuelos MG,Sun L,O'Dowd DK,Schwartz PH||Journal of neuroscience research (91:1247)||2013|
Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons.
51-6900 was used in immunocytochemistry to investigate the role of NRG1 in postsynaptic differentiation in GABAergic interneurons.
|Ting AK,Chen Y,Wen L,Yin DM,Shen C,Tao Y,Liu X,Xiong WC,Mei L||The Journal of neuroscience : the official journal of the Society for Neuroscience (31:15)||2011|
Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.
51-6900 was used in immunohistochemistry to investigate the role of huntingtin in normal excitatory synapse development in cortical and striatal circuits
|McKinstry SU,Karadeniz YB,Worthington AK,Hayrapetyan VY,Ozlu MI,Serafin-Molina K,Risher WC,Ustunkaya T,Dragatsis I,Zeitlin S,Yin HH,Eroglu C||The Journal of neuroscience : the official journal of the Society for Neuroscience (34:9455)||2014|
Delayed appearance of the scaffolding proteins PSD-95 and Homer-1 at the developing rat calyx of Held synapse.
51-6900 was used in immunohistochemistry to study the development of rat calyx of Held synapse
|Soria Van Hoeve JS,Borst JG||The Journal of comparative neurology (518:4581)||2010|
|Rat||Not Cited||Regenerating motor bridge axons refine connections and synapse on lumbar motoneurons to bypass chronic spinal cord injury.||Campos LW,Chakrabarty S,Haque R,Martin JH||The Journal of comparative neurology (506:838)||2008|
|Mouse||Not Cited||Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease.||Cepeda C,Hurst RS,Calvert CR,Hernández-Echeagaray E,Nguyen OK,Jocoy E,Christian LJ,Ariano MA,Levine MS||The Journal of neuroscience : the official journal of the Society for Neuroscience (23:961)||2003|
discs large homolog 4; disks large homolog 4; Dlg4; Post Synaptic Density; post-synaptic density protein 95; postsynaptic density protein 95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; PSD95; SAP-90; SAP90; Synapse Associated Protein 95 kDa; synapse-associated protein 90; synapse-associated protein SAP90; Tax interaction protein 15
DLG4; Dlgh4; PSD-95; PSD95; SAP-90; SAP90; SAP90A