Product References
DLK-MAPK Signaling Coupled with DNA Damage Promotes Intrinsic Neurotoxicity Associated with Non-Mutated Tau.
Molecular neurobiology
Li S,Roy ER,Wang Y,Watkins T,Cao W
51-6900 was used in Immunocytochemistry to establish a cellular tauopathy model highly relevant to AD and identified a functional synergy between the DLK-MAPK axis and DNA damage response in the neuronal degenerative process.
Wed May 01 00:00:00 UTC 2024
Neuronal transcriptome, tau and synapse loss in Alzheimer's knock-in mice require prion protein.
Alzheimer's research & therapy
Stoner A,Fu L,Nicholson L,Zheng C,Toyonaga T,Spurrier J,Laird W,Cai Z,Strittmatter SM
51-6900 was used in Immunohistochemistry to examine the necessity of cellular prion protein (PrPC) as a function of age in homozygous AppNL-G-F/hMapt double knock-in mice (DKI).
Wed Nov 15 00:00:00 UTC 2023
Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease.
Cell reports
Mansky RH,Greguske EA,Yu D,Zarate N,Intihar TA,Tsai W,Brown TG,Thayer MN,Kumar K,Gomez-Pastor R
51-6900 was used in Immunohistochemistry (Frozen) to show the mechanism connecting p53 stabilization with HSF1 degradation and pathophysiology in HD and sheds light on the broader molecular differences and commonalities between cancer and neurodegeneration.
Tue Mar 28 00:00:00 UTC 2023
Maternal diet during early gestation influences postnatal taste activity-dependent pruning by microglia.
The Journal of experimental medicine
Sun C,Zheng S,Perry JSA,Norris GT,Cheng M,Kong F,Skyberg R,Cang J,Erisir A,Kipnis J,Hill DL
51-6900 was used in Immunohistochemistry to study gustatory terminal field maturation in the postnatal mouse nucleus of the solitary tract (NST) during normal development and in mice where their mothers were fed a low NaCl diet for a limited period soon after conception.
Mon Dec 04 00:00:00 UTC 2023
δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions.
The Journal of cell biology
Tan CX,Bindu DS,Hardin EJ,Sakers K,Baumert R,Ramirez JJ,Savage JT,Eroglu C
51-6900 was used in Immunohistochemistry to show that δ-catenin controls astrocyte-neuron cadherin interactions that regulate layer-specific astrocyte morphogenesis.
Mon Nov 06 00:00:00 UTC 2023
Cortex-restricted deletion of Foxp1 impairs barrel formation and induces aberrant tactile responses in a mouse model of autism.
Molecular autism
Li X,Hao S,Zou S,Tu X,Kong W,Jiang T,Chen JG
51-6900 was used in Immunohistochemistry (Frozen) to present anatomical evidence for reduced thalamocortical connectivity in a genetic mouse model of ASD and demonstrates that the cerebral cortex can be the origin of atypical sensory behaviors.
Mon Sep 11 00:00:00 UTC 2023
Postnatal expression of CD38 in astrocytes regulates synapse formation and adult social memory.
The EMBO journal
Hattori T,Cherepanov SM,Sakaga R,Roboon J,Nguyen DT,Ishii H,Takarada-Iemata M,Nishiuchi T,Kannon T,Hosomichi K,Tajima A,Yamamoto Y,Okamoto H,Sugawara A,Higashida H,Hori O
51-6900 was used in Western Blotting to demonstrate a novel developmental role of astrocytes in neural circuit formation and regulation of social behavior in adults.
Tue Aug 01 00:00:00 UTC 2023
Disrupting cortical astrocyte Ca2+ signaling in developing brain induces social deficits and depressive-like behaviors.
Glia
Luo R,Zhou B,Liao P,Zuo Y,Jiang R
51-6900 was used in Immunohistochemistry (Frozen) to demonstrate that the integrity of cortical astrocyte Ca2+ signaling in developing mice is critical for neural circuit development and may be involved in the pathogenesis of developmental neuropsychiatric diseases, such as autism spectrum disorders and depression.
Sat Jul 01 00:00:00 UTC 2023
Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons.
Theranostics
Beatriz M,Rodrigues RJ,Vilaça R,Egas C,Pinheiro PS,Daley GQ,Schlaeger TM,Raimundo N,Rego AC,Lopes C
51-6900 was used in Western Blotting to find that Huntington's disease (HD)-derived neurons displayed reduced density of inhibitory synapse markers and GABA receptor-mediated ionotropic signaling.
Mon Jul 17 00:00:00 UTC 2023
Defects in early synaptic formation and neuronal function in Prader-Willi syndrome.
Scientific reports
Soeda S,Ito D,Ogushi T,Sano Y,Negoro R,Fujita T,Saito R,Taniura H
51-6900 was used in Immunocytochemistry to identify SLITRK1 as a downregulated gene in NSCs differentiated from PWS patient iPS cells by RNA sequencing analysis.
Tue Jul 25 00:00:00 UTC 2023
Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Akdemir ES,Woo J,Bosquez Huerta NA,Lozzi B,Groves AK,Harmanci AS,Deneen B
51-6900 was used in Immunohistochemistry to show that the Lunatic Fringe-GFP (Lfng-GFP) bacteria artificial chromosome mouse line from both sexes specifically labels astrocyte populations within lamina III and IV of the dorsal spinal cord.
Wed Jan 26 00:00:00 UTC 2022
ErbB4 in parvalbumin-positive interneurons mediates proactive interference in olfactory associative reversal learning.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Xu Y,Wang ML,Tao H,Geng C,Guo F,Hu B,Wang R,Hou XY
51-6900 was used in Immunohistochemistry to provide novel insight into the physiological role of PV interneuron ErbB4 signaling in cognitive processes and reveal an associative learning-related transsynaptic NRXN1β-ErbB4-PSD-95 complex that affects the ERK1/2-BDNF pathway and underlies local inhibitory circuit plasticity and proactive interference.
Wed Jun 01 00:00:00 UTC 2022
A key role of miR-132-5p in the prefrontal cortex for persistent prophylactic actions of (R)-ketamine in mice.
Translational psychiatry
Ma L,Wang L,Chang L,Shan J,Qu Y,Wang X,Wan X,Fujita Y,Hashimoto K
51-6900 was used in Western Blotting to show a novel role of miR-132-5p in the prefrontal cortex underlying depression-like phenotypes in chronic restraint stress model and the sustained prophylactic effects of (R)-ketamine.
Wed Sep 28 00:00:00 UTC 2022
Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques.
Immunity
Roy ER,Chiu G,Li S,Propson NE,Kanchi R,Wang B,Coarfa C,Zheng H,Cao W
51-6900 was used in Immunohistochemistry to reveal brain-wide cellular reactions to type I interferon (IFN-I), an innate immune cytokine aberrantly elicited by amyloid β plaques, and examined their role in cognition and neuropathology relevant to AD in a murine amyloidosis model.
Tue May 10 00:00:00 UTC 2022
lncRNA Neat1 regulates neuronal dysfunction post-sepsis via stabilization of hemoglobin subunit beta.
Molecular therapy : the journal of the American Society of Gene Therapy
Wu Y,Li P,Liu L,Goodwin AJ,Halushka PV,Hirose T,Nakagawa S,Zhou J,Liu M,Fan H
51-6900 was used in Western Blotting to uncover a previously unknown mechanism of the Neat1/Hbb axis in regulating neuronal dysfunction, which may lead to a novel treatment strategy for SAE.
Wed Jul 06 00:00:00 UTC 2022
Fecal microbiota transplantation from patients with rheumatoid arthritis causes depression-like behaviors in mice through abnormal T cells activation.
Translational psychiatry
Pu Y,Zhang Q,Tang Z,Lu C,Wu L,Zhong Y,Chen Y,Hashimoto K,Luo Y,Liu Y
51-6900 was used in Western Blotting to suggest that CIA mice exhibit depression-like behaviors, systemic inflammation, and abnormal composition of gut microbiota, and that FMT from RA patients produces depression-like behaviors in ABX-treated mice via T cells differentiation.
Wed Jun 01 00:00:00 UTC 2022
Local targets of T-stellate cells in the ventral cochlear nucleus.
The Journal of comparative neurology
Lin L,Campbell J,Oertel D,Smith PH
51-6900 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to indicate that, in addition to their auditory nerve input, T-stellate cells provide a second modulatable excitatory input to both inhibitory and excitatory cells in a VCN isofrequency lamina and may play a significant role in acoustic information processing.
Tue Nov 01 00:00:00 UTC 2022
Adaptable toolbox to characterize Alzheimer's disease pathology in mouse models.
STAR protocols
Huang Y,Lemke G
51-6900 was used in Immunohistochemistry (PFA fixed) to describe a highly adaptable toolbox for characterizing and analyzing molecular and histopathological changes in Alzheimer's disease (AD) mouse models.
Fri Dec 16 00:00:00 UTC 2022
Regulation of prefrontal patterning and connectivity by retinoic acid.
Nature
Shibata M,Pattabiraman K,Lorente-Galdos B,Andrijevic D,Kim SK,Kaur N,Muchnik SK,Xing X,Santpere G,Sousa AMM,Sestan N
51-6900 was used in Immunohistochemistry to investigate if retinoic acid signalling has a critical role in the development of the prefrontal cortex.
Fri Oct 01 00:00:00 UTC 2021
Microglia use TAM receptors to detect and engulf amyloid β plaques.
Nature immunology
Huang Y,Happonen KE,Burrola PG,O'Connor C,Hah N,Huang L,Nimmerjahn A,Lemke G
51-6900 was used in Immunohistochemistry to investigate if the TAM system is an essential mediator of microglial recognition and engulfment of amyloid plaques and if TAM-driven microglial phagocytosis does not inhibit, but rather promotes, dense-core plaque development.
Sat May 01 00:00:00 UTC 2021
C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation.
Neuron
Lall D,Lorenzini I,Mota TA,Bell S,Mahan TE,Ulrich JD,Davtyan H,Rexach JE,Muhammad AKMG,Shelest O,Landeros J,Vazquez M,Kim J,Ghaffari L,O'Rourke JG,Geschwind DH,Blurton-Jones M,Holtzman DM,Sattler R,Baloh RH
51-6900 was used in Western Blotting to suggest that altered microglial function due to decreased C9orf72 expression directly contributes to neurodegeneration in repeat expansion carriers independent of gain-of-function toxicities.
Wed Jul 21 00:00:00 UTC 2021
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
Neuron
Wang C,Xiong M,Gratuze M,Bao X,Shi Y,Andhey PS,Manis M,Schroeder C,Yin Z,Madore C,Butovsky O,Artyomov M,Ulrich JD,Holtzman DM
51-6900 was used in Immunocytochemistry-immunoflourescence to investigate The cell-specific role of each form of apoE in the setting of neurodegeneration.
Wed May 19 00:00:00 UTC 2021
TLR4 pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury.
British journal of pharmacology
Rosa JM,Farré-Alins V,Ortega MC,Navarrete M,Lopez-Rodriguez AB,Palomino-Antolín A,Fernández-López E,Vila-Del Sol V,Decouty C,Narros-Fernández P,Clemente D,Egea J
51-6900 was used in Immunohistochemistry to demonstrate that TLR4-mediated signalling, most probably through microglia and/or infiltrated monocyte-astrocyte communication, plays a crucial role in the TBI pathophysiology and that its inhibition prevents synaptic loss and BBB damage accelerating tissue recovery/repair, which might represent a therapeutic potential in CNS injuries and disorders.
Wed Sep 01 00:00:00 UTC 2021
Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nakamura Y,Ueno M,Niehaus JK,Lang RA,Zheng Y,Yoshida Y
51-6900 was used in Immunohistochemistry to demonstrate a potential molecular approach to reconstruct motor pathways after SCI.
Wed Dec 15 00:00:00 UTC 2021
SEQUIN: An imaging and analysis platform for quantification and characterization of synaptic structures in mouse.
STAR protocols
Reitz SJ,Sauerbeck AD,Kummer TT
51-6900 was used in Immunocytochemistry to describe quantification of synaptic loci using SEQUIN.
Fri Mar 19 00:00:00 UTC 2021
Neurodegeneration Induced by Anti-IgLON5 Antibodies Studied in Induced Pluripotent Stem Cell-Derived Human Neurons.
Cells
Ryding M,Gamre M,Nissen MS,Nilsson AC,Okarmus J,Poulsen AAE,Meyer M,Blaabjerg M
51-6900 was used in Immunocytochemistry to highlight the potential use of stem cell-based in vitro models for investigations of antibody-mediated diseases.
Thu Apr 08 00:00:00 UTC 2021
Alterations in Excitatory and Inhibitory Synaptic Development Within the Mesolimbic Dopamine Pathway in a Mouse Model of Prenatal Drug Exposure.
Frontiers in pediatrics
Boggess T,Williamson JC,Niebergall EB,Sexton H,Mazur A,Egleton RD,Grover LM,Risher WC
51-6900 was used in Immunohistochemistry to investigate the effects of prenatal drug exposure on synaptic connectivity within brain regions associated with the mesolimbic dopamine pathway, the primary reward pathway associated with drug abuse and addiction, in a mouse model.
Fri Apr 05 00:00:00 UTC 2024
Generation of human pluripotent stem cell-derived fused organoids with oligodendroglia and myelin.
STAR protocols
Kim H,Jiang P
51-6900 was used in Immunocytochemistry to demonstrate a step-by-step protocol for generating fused forebrain organoids derived from human pluripotent stem cells.
Fri Jun 18 00:00:00 UTC 2021
Downregulation of CD40L-CD40 attenuates seizure susceptibility and severity of seizures.
Scientific reports
Pototskiy E,Vinokuroff K,Ojeda A,Major CK,Sharma D,Anderson T,Howard K,Borenstein R,Musto AE
51-6900 was used in Immunohistochemistry to determine the effect of CD40-CD40L activation in experimental seizures.
Thu Aug 26 00:00:00 UTC 2021
Heterophyllin B, a cyclopeptide from Pseudostellaria heterophylla, enhances cognitive function via neurite outgrowth and synaptic plasticity.
Phytotherapy research : PTR
Yang Z,Zhang C,Li X,Ma Z,Ge Y,Qian Z,Song C
51-6900 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to show that the traditional Chinese medicine Pseudostellaria heterophylla promotes neurite regrowth and enhanced cognitive function in normal mice.
Wed Sep 01 00:00:00 UTC 2021
Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids.
Cell stem cell
Popova G,Soliman SS,Kim CN,Keefe MG,Hennick KM,Jain S,Li T,Tejera D,Shin D,Chhun BB,McGinnis CS,Speir M,Gartner ZJ,Mehta SB,Haeussler M,Hengen KB,Ransohoff RR,Piao X,Nowakowski TJ
51-6900 was used in Immunohistochemistry (Frozen) to compare human microglia states across culture models, including cultured primary and pluripotent stem cell-derived microglia.
Thu Dec 02 00:00:00 UTC 2021
Adenosine A2B receptor down-regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development.
Glia
Tanaka M,Shigetomi E,Parajuli B,Nagatomo H,Shinozaki Y,Hirayama Y,Saito K,Kubota Y,Danjo Y,Lee JH,Kim SK,Nabekura J,Koizumi S
51-6900 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to reveal that A2B receptor is critical for down-regulation of mGluR5 in astrocytes, contributing to termination of excess synaptogenesis during development.
Mon Nov 01 00:00:00 UTC 2021
P62 accumulates through neuroanatomical circuits in response to tauopathy propagation.
Acta neuropathologica communications
Blaudin de Thé FX,Lassus B,Schaler AW,Fowler SL,Goulbourne CN,Jeggo R,Mannoury la Cour C,Millan MJ,Duff KE
51-6900 was used in Immunohistochemistry to examine the relationship between trans-synaptic transfer and accumulation of pathological tau from donor to recipient neurons to understand underlying mechanisms in Alzheimer''s disease progression.
Tue Nov 02 00:00:00 UTC 2021
Neuronal VCP loss of function recapitulates FTLD-TDP pathology.
Cell reports
Wani A,Zhu J,Ulrich JD,Eteleeb A,Sauerbeck AD,Reitz SJ,Arhzaouy K,Ikenaga C,Yuede CM,Pittman SK,Wang F,Li S,Benitez BA,Cruchaga C,Kummer TT,Harari O,Chou TF,Schröder R,Clemen CS,Weihl CC
51-6900 was used in Western Blot to identify a loss of VCP-dependent functions as a mediator of FTLD-TDP and reveal an unexpected biochemical similarity with progranulin deficiency.
Tue Jul 20 00:00:00 UTC 2021
Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1.
Cells
Yong HJ,Hwang JI,Seong JY
51-6900 was used in ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to suggest that FAM19A1 participates in dendritic spine development and neurite arborization.
Fri Jul 23 00:00:00 UTC 2021
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
The Journal of clinical investigation
Gratuze M,Leyns CE,Sauerbeck AD,St-Pierre MK,Xiong M,Kim N,Serrano JR,Tremblay MÈ,Kummer TT,Colonna M,Ulrich JD,Holtzman DM
51-6900 was used in Immunohistochemistry (Paraffin), Immunohistochemistry to suggest that impaired TREM2 signaling reduces microglia-mediated neurodegeneration in the setting of tauopathy.
Tue Sep 01 00:00:00 UTC 2020
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
The Journal of clinical investigation
Gratuze M,Leyns CE,Sauerbeck AD,St-Pierre MK,Xiong M,Kim N,Serrano JR,Tremblay MÈ,Kummer TT,Colonna M,Ulrich JD,Holtzman DM
51-6900 was used in Immunohistochemistry (Paraffin), Immunohistochemistry to suggest that impaired TREM2 signaling reduces microglia-mediated neurodegeneration in the setting of tauopathy.
Tue Sep 01 00:00:00 UTC 2020
SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury.
Neuron
Sauerbeck AD,Gangolli M,Reitz SJ,Salyards MH,Kim SH,Hemingway C,Gratuze M,Makkapati T,Kerschensteiner M,Holtzman DM,Brody DL,Kummer TT
51-6900 was used in Immunohistochemistry to describe a rapid, accessible super-resolution imaging and analysis workflow-SEQUIN-that quantifies central synapses in human tissue and animal models, characterizes their nanostructural and molecular features, and enables volumetric imaging of mesoscale synaptic networks without the production of large histological arrays.
Wed Jul 22 00:00:00 UTC 2020
Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia.
The EMBO journal
Scott-Hewitt N,Perrucci F,Morini R,Erreni M,Mahoney M,Witkowska A,Carey A,Faggiani E,Schuetz LT,Mason S,Tamborini M,Bizzotto M,Passoni L,Filipello F,Jahn R,Stevens B,Matteoli M
51-6900 was used in Immunohistochemistry to provide mechanistic insight into microglial-mediated synapse pruning and identify a novel role of developmentally regulated neuronal PS exposure that is common among developing brain structures.
Mon Aug 17 00:00:00 UTC 2020
Spinal Wnt5a Plays a Key Role in Spinal Dendritic Spine Remodeling in Neuropathic and Inflammatory Pain Models and in the Proalgesic Effects of Peripheral Wnt3a.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Simonetti M,Kuner R
51-6900 was used in Immunohistochemistry to investigate the role of Wnt5a signalling in modulation of chronic pain using mouse models.
Wed Aug 26 00:00:00 UTC 2020
Cerebellospinal Neurons Regulate Motor Performance and Motor Learning.
Cell reports
Sathyamurthy A,Barik A,Dobrott CI,Matson KJE,Stoica S,Pursley R,Chesler AT,Levine AJ
51-6900 was used in Immunohistochemistry-immunofluorescence to establish CeS neurons as a critical component of the neural circuitry for skilled movements and provides insights into the organizational logic of motor networks.
Tue May 12 00:00:00 UTC 2020
A key role of the subdiaphragmatic vagus nerve in the depression-like phenotype and abnormal composition of gut microbiota in mice after lipopolysaccharide administration.
Translational psychiatry
Zhang J,Ma L,Chang L,Pu Y,Qu Y,Hashimoto K
51-6900 was used in Western Blotting to investigate the effects of subdiaphragmatic vagotomy (SDV) on the depression-like phenotype and the abnormal composition of gut microbiota in mice after lipopolysaccharide (LPS) administration.
Tue Jun 09 00:00:00 UTC 2020
Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations.
eLife
Chen C,Soto G,Dumrongprechachan V,Bannon N,Kang S,Kozorovitskiy Y,Parisiadou L
51-6900 was used in Immunocytochemistry to show that R1441C and G2019S knock-in mice enabled thorough evaluation of dendritic spines and synapses on pathway-identified SPNs.
Fri Oct 02 00:00:00 UTC 2020
Effects of Dexamethasone on Remodeling of the Hippocampal Synaptic Filamentous Actin Cytoskeleton in a Model of Pilocarpine-induced Status Epilepticus.
International journal of medical sciences
Yang N,Zhang Y,Wang JT,Chen C,Song Y,Liang JM,Ma DH,Zhang YF
51-6900 was used in Immunohistochemistry-immunofluorescence to indicate that treatment with dexamethasone stabilizes the synaptic F-actin cytoskeleton and reduces the damage to the brain due to status epilepticus (SE), which is expected to be beneficial in alleviating delayed neuron damage and the process of epileptogenesis.
Tue Jun 01 00:00:00 UTC 2021
Individual brain organoids reproducibly form cell diversity of the human cerebral cortex.
Nature
Velasco S,Kedaigle AJ,Simmons SK,Nash A,Rocha M,Quadrato G,Paulsen B,Nguyen L,Adiconis X,Regev A,Levin JZ,Arlotta P
51-6900 was used in Immunohistochemistry-immunofluorescence to show that an organoid model of the dorsal forebrain can reliably generate a rich diversity of cell types appropriate for the human cerebral cortex.
Sat Jun 01 00:00:00 UTC 2019
OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome.
Cell stem cell
Xu R,Brawner AT,Li S,Liu JJ,Kim H,Xue H,Pang ZP,Kim WY,Hart RP,Liu Y,Jiang P
51-6900 was used in Immunohistochemistry-immunofluorescence to conclude that altered OLIG2 expression may underlie neurodevelopmental abnormalities and cognitive defects in DS patients.
Thu Jun 06 00:00:00 UTC 2019
Astroglial dysfunctions drive aberrant synaptogenesis and social behavioral deficits in mice with neonatal exposure to lengthy general anesthesia.
PLoS biology
Zhou B,Chen L,Liao P,Huang L,Chen Z,Liao D,Yang L,Wang J,Yu G,Wang L,Zhang J,Zuo Y,Liu J,Jiang R
51-6900 was used in Immunohistochemistry to report that sevoflurane (Sevo), a commonly used GA in pediatrics, caused compromised astrocyte morphogenesis spatiotemporally correlated to synaptic overgrowth, with reduced synaptic function in developing cortex in a regional-, exposure-length-, and age-specific manner.
Thu Aug 01 00:00:00 UTC 2019
Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Salazar SV,Cox TO,Lee S,Brody AH,Chyung AS,Haas LT,Strittmatter SM
51-6900 was used in Western Blotting to show that the risk factor Pyk2 localizes specifically to neurons in adult brain.
Wed Jan 23 00:00:00 UTC 2019
Disturbed Prefrontal Cortex Activity in the Absence of Schizophrenia-Like Behavioral Dysfunction in Arc/Arg3.1 Deficient Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gao X,Grendel J,Muhia M,Castro-Gomez S,Süsens U,Isbrandt D,Kneussel M,Kuhl D,Ohana O
51-6900 was used in Immunohistochemistry-immunofluorescence to demonstrate that genetic deletion of Arc/Arg3.1 before puberty alters synaptic function and prefrontal cortex activity.
Wed Oct 09 00:00:00 UTC 2019
Anti-PrPC antibody rescues cognition and synapses in transgenic alzheimer mice.
Annals of clinical and translational neurology
Cox TO,Gunther EC,Brody AH,Chiasseu MT,Stoner A,Smith LM,Haas LT,Hammersley J,Rees G,Dosanjh B,Groves M,Gardener M,Dobson C,Vaughan T,Chessell I,Billinton A,Strittmatter SM
51-6900 was used in Immunohistochemistry-immunofluorescence to evaluate the preclinical therapeutic efficacy of a fully human monoclonal antibody against cellular prion protein.
Fri Mar 01 00:00:00 UTC 2019
Deletion of Dtnbp1 in mice impairs threat memory consolidation and is associated with enhanced inhibitory drive in the amygdala.
Translational psychiatry
Huang CCY,Muszynski KJ,Bolshakov VY,Balu DT
51-6900 was used in Western Blotting to elucidate a role for dysbindin-1 in the regulation of amygdalar function.
Tue Apr 09 00:00:00 UTC 2019
Wheel Running Improves Motor Function and Spinal Cord Plasticity in Mice With Genetic Absence of the Corticospinal Tract.
Frontiers in cellular neuroscience
Zhang W,Yang B,Weng H,Liu T,Shi L,Yu P,So KF,Qu Y,Zhou L
51-6900 was used in Western Blotting to investigate whether voluntary wheel running could further improve locomotor plasticity in corticospinal tract-deficient mice.
Wed Sep 30 00:00:00 UTC 2020
Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.
Cell reports
Gunther EC,Smith LM,Kostylev MA,Cox TO,Kaufman AC,Lee S,Folta-Stogniew E,Maynard GD,Um JW,Stagi M,Heiss JK,Stoner A,Noble GP,Takahashi H,Haas LT,Schneekloth JS,Merkel J,Teran C,Naderi ZK,Supattapone S,Strittmatter SM
51-6900 was used in Immunohistochemistry to study the use of an orally active cellular prion protein-directed polymeric agent in the treatment of neurodegeneration in Alzheimer's disease and transmissible spongiform encephalopathy.
Wed Jan 02 00:00:00 UTC 2019
Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis.
Acta neuropathologica communications
Gomez-Giro G,Arias-Fuenzalida J,Jarazo J,Zeuschner D,Ali M,Possemis N,Bolognin S,Halder R,Jäger C,Kuper WFE,van Hasselt PM,Zaehres H,Del Sol A,van der Putten H,Schöler HR,Schwamborn JC
51-6900 was used in Immunohistochemistry-immunofluorescence to suggest that a mutation in CLN3 severely affects brain development.
Mon Dec 30 00:00:00 UTC 2019
Astrocyte-Secreted Chordin-like 1 Drives Synapse Maturation and Limits Plasticity by Increasing Synaptic GluA2 AMPA Receptors.
Neuron
Blanco-Suarez E,Liu TF,Kopelevich A,Allen NJ
51-6900 was used in Immunohistochemistry to study the essential switch of calcium-permeable AMPA glutamate receptors (AMPARs) that are subsequently replaced with GluA2-containing calcium-impermeable AMPARs and neuronal synapse maturation is regulated by astrocytes.
Wed Dec 05 00:00:00 UTC 2018
Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury.
The Journal of experimental medicine
Norris GT,Smirnov I,Filiano AJ,Shadowen HM,Cody KR,Thompson JA,Harris TH,Gaultier A,Overall CC,Kipnis J
51-6900 was used in Immunohistochemistry-immunofluorescence to investigate how neurodegenerative debris is cleared by microglia and develop a model for studying its mechanisms and physiological roles.
Mon Jul 02 00:00:00 UTC 2018
Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1.
The Journal of cell biology
Risher WC,Kim N,Koh S,Choi JE,Mitev P,Spence EF,Pilaz LJ,Wang D,Feng G,Silver DL,Soderling SH,Yin HH,Eroglu C
51-6900 was used in Immunohistochemistry to study the mechanism by which the thrombospondin-α2δ-1 interaction promotes synaptogenesis, and the requirement for α2δ-1 for connectivity of the developing mammalian brain.
Mon Oct 01 00:00:00 UTC 2018
Subretinal Human Umbilical Tissue-Derived Cell Transplantation Preserves Retinal Synaptic Connectivity and Attenuates Müller Glial Reactivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Koh S,Chen WJ,Dejneka NS,Harris IR,Lu B,Girman S,Saylor J,Wang S,Eroglu C
51-6900 was used in Immunocytochemistry to investigate the progression of synapse and photoreceptor loss and whether human umbilical tissue-derived cells treatment preserves photoreceptors and synaptic connectivity in the Royal College of Surgeons rats of both sexes.
Wed Mar 21 00:00:00 UTC 2018
Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model.
Neuropharmacology
Smith LM,Zhu R,Strittmatter SM
51-6900 was used in Immunohistochemistry-immunofluorescence to investigate whether saracatinib provides persistent improvement in symptoms after therapy withdrawal in a transgenic Alzheimer's disease model.
Thu Mar 01 00:00:00 UTC 2018
Developmental pattern and structural factors of dendritic survival in cerebellar granule cells in vivo.
Scientific reports
Dhar M,Hantman AW,Nishiyama H
51-6900 was used in Immunohistochemistry to study developmental refinement of granule cell dendritic arbors and its relation to synapse formation.
Mon Dec 03 00:00:00 UTC 2018
Human neuroepithelial stem cell regional specificity enables spinal cord repair through a relay circuit.
Nature communications
Dell'Anno MT,Wang X,Onorati M,Li M,Talpo F,Sekine Y,Ma S,Liu F,Cafferty WBJ,Sestan N,Strittmatter SM
51-6900 was used in Immunocytochemistry-immunoflourescence to demonstrate that human neuroepithelial stem cells may provide an anatomically specific relay function for spinal cord injury recovery.
Fri Aug 24 00:00:00 UTC 2018
Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity.
Nature communications
He HY,Shen W,Zheng L,Guo X,Cline HT
51-6900 was used in Immunohistochemistry-immunofluorescence to investigate the effects of decreased glutamatergic synaptic input on inhibitory synapses in developing Xenopus tectal neurons.
Tue Jul 24 00:00:00 UTC 2018
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
Acta neuropathologica
Takahashi H,Klein ZA,Bhagat SM,Kaufman AC,Kostylev MA,Ikezu T,Strittmatter SM
516900 was used in immunohistochemistry to see that the granulin Alzheimer's disease risk variant has no significant effects on florbetapir positron emission tomographic amyloid imaging and cerebrospinal fluid Abeta levels
Mon May 01 00:00:00 UTC 2017
Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Salazar SV,Gallardo C,Kaufman AC,Herber CS,Haas LT,Robinson S,Manson JC,Lee MK,Strittmatter SM
51-6900 was used in Immunohistochemistry-floating tissue to study the role of amyloid-Β binding cellular prion protein in rescuing or halting established Alzheimer's disease endophenotypes.
Wed Sep 20 00:00:00 UTC 2017
Electrical Stimulation Using Conductive Polymer Polypyrrole Counters Reduced Neurite Outgrowth of Primary Prefrontal Cortical Neurons from NRG1-KO and DISC1-LI Mice.
Scientific reports
Zhang Q,Esrafilzadeh D,Crook JM,Kapsa R,Stewart EM,Tomaskovic-Crook E,Wallace GG,Huang XF
516900 was used in western blot to assess the use of the electroactive conductive polymer polypyrrole to counter impaired neurite outgrowth of primary pre-frontal cortical neurons
Wed Feb 15 00:00:00 UTC 2017
Immature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: a model for schizophrenia and intellectual disability.
Molecular brain
Nakao A,Miyazaki N,Ohira K,Hagihara H,Takagi T,Usuda N,Ishii S,Murata K,Miyakawa T
51-6900 was used in Immunohistochemistry to suggest that Schnurri-2 knockout mice serve as a tool for investigating morphological abnormalities of subcellular-scale structures in schizophrenia and intellectual disability.
Tue Dec 12 00:00:00 UTC 2017
Neurodevelopmental Changes in Excitatory Synaptic Structure and Function in the Cerebral Cortex of Sanfilippo Syndrome IIIA Mice.
Scientific reports
Dwyer CA,Scudder SL,Lin Y,Dozier LE,Phan D,Allen NJ,Patrick GN,Esko JD
516900 was used in immunohistochemistry - frozen section to assess the contribution of storage in postnatal neurodevelopment
Tue Apr 18 00:00:00 UTC 2017
Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease.
Brain : a journal of neurology
Haas LT,Salazar SV,Kostylev MA,Um JW,Kaufman AC,Strittmatter SM
51-6900 was used in immunohistochemistry to study the coupling of cellular prion protein to intracellular signaling in Alzheimer's disease by metabotropic glutamate receptor 5
Mon Feb 01 00:00:00 UTC 2016
ON and OFF retinal ganglion cells differentially regulate serotonergic and GABAergic activity in the dorsal raphe nucleus.
Scientific reports
Zhang T,Huang L,Zhang L,Tan M,Pu M,Pickard GE,So KF,Ren C
51-6900 was used in immunohistochemistry to investigate differential regulation of serotonergic and GABAergic activity in the dorsal raphe nucleus by ON and OFF retinal ganglion cells
Mon May 16 00:00:00 UTC 2016
Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb.
Nature communications
Breton-Provencher V,Bakhshetyan K,Hardy D,Bammann RR,Cavarretta F,Snapyan M,Côté D,Migliore M,Saghatelyan A
51-6900 was used in immunohistochemistry study the structural remodeling of spines in the olfactory bulb
Wed Aug 31 00:00:00 UTC 2016
An alternative splicing switch shapes neurexin repertoires in principal neurons versus interneurons in the mouse hippocampus.
eLife
Nguyen TM,Schreiner D,Xiao L,Traunmüller L,Bornmann C,Scheiffele P
516900 was used in western blot to identify a role for parvalbumin-positive-cell-specific alternative splicing of neurexins in neuronal circuit function
Tue Dec 13 00:00:00 UTC 2016
Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Kim E,Woo MS,Qin L,Ma T,Beltran CD,Bao Y,Bailey JA,Corbett D,Ratan RR,Lahiri DK,Cho S
51-6900 was used in western blot to elucidate functional recovery in chronic stroke promoted by daidzen augments cholesterol homeostasis via ApoE
Wed Nov 11 00:00:00 UTC 2015
Expression of the postsynaptic scaffold PSD-95 and development of synaptic physiology during giant terminal formation in the auditory brainstem of the chicken.
The European journal of neuroscience
Goyer D,Fensky L,Hilverling AM,Kurth S,Kuenzel T
51-6900 was used in western blot to study the expression of PSD-95 during the transition from bouton-to-endbulb synapses.
Fri May 01 00:00:00 UTC 2015
Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model.
Alzheimer's research & therapy
Nygaard HB,Kaufman AC,Sekine-Konno T,Huh LL,Going H,Feldman SJ,Kostylev MA,Strittmatter SM
51-6900 was used in immunohistochemistry to study epileptiform activity mouse models of Alzheimer's disease.
Wed May 06 00:00:00 UTC 2015
REDD1 is essential for stress-induced synaptic loss and depressive behavior.
Nature medicine
Ota KT,Liu RJ,Voleti B,Maldonado-Aviles JG,Duric V,Iwata M,Dutheil S,Duman C,Boikess S,Lewis DA,Stockmeier CA,DiLeone RJ,Rex C,Aghajanian GK,Duman RS
51-6900 was used in western blot to identify REDD as a mediator neuronal atrophy and depressive behavior caused by chronic stress exposure.
Thu May 01 00:00:00 UTC 2014
Identification of a cellular node for motor control pathways.
Nature neuroscience
Levine AJ,Hinckley CA,Hilde KL,Driscoll SP,Poon TH,Montgomery JM,Pfaff SL
51-6900 was used in immunohistochemistry to identify a population of motor synergy encoder neurons in the mouse spinal cord that may represent a central node in neural pathways for voluntary and reflexive movement.
Tue Apr 01 00:00:00 UTC 2014
Rapid neurogenesis through transcriptional activation in human stem cells.
Molecular systems biology
Busskamp V,Lewis NE,Guye P,Ng AH,Shipman SL,Byrne SM,Sanjana NE,Murn J,Li Y,Li S,Stadler M,Weiss R,Church GM
51-6900 was used in immunocytochemistry to describe a method to rapidly generate neurons from human-induced pluripotent stem cells to elucidate the underlying regulatory programs
Mon Nov 17 00:00:00 UTC 2014
Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.
The Journal of neuroscience : the official journal of the Society for Neuroscience
McKinstry SU,Karadeniz YB,Worthington AK,Hayrapetyan VY,Ozlu MI,Serafin-Molina K,Risher WC,Ustunkaya T,Dragatsis I,Zeitlin S,Yin HH,Eroglu C
51-6900 was used in immunohistochemistry to investigate the role of huntingtin in normal excitatory synapse development in cortical and striatal circuits
Wed Jul 09 00:00:00 UTC 2014
Process-based expansion and neural differentiation of human pluripotent stem cells for transplantation and disease modeling.
Journal of neuroscience research
Stover AE,Brick DJ,Nethercott HE,Banuelos MG,Sun L,O'Dowd DK,Schwartz PH
51-6900 was used in immunocytochemistry to evaluate a cell culture system for long-term passaging of human pluripotent stem cells
Tue Oct 01 00:00:00 UTC 2013
Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.
Nature neuroscience
Um JW,Nygaard HB,Heiss JK,Kostylev MA,Stagi M,Vortmeyer A,Wisniewski T,Gunther EC,Strittmatter SM
51-6900 was used in immunocytochemistry to determine the specificity, distribution, and signaling of amyloid-beta and cellular prion protein complexes
Sat Sep 01 00:00:00 UTC 2012
Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling.
Human molecular genetics
Renvoisé B,Stadler J,Singh R,Bakowska JC,Blackstone C
Wed Aug 15 00:00:00 UTC 2012
Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing.
Cell death and differentiation
Zimmer B,Kuegler PB,Baudis B,Genewsky A,Tanavde V,Koh W,Tan B,Waldmann T,Kadereit S,Leist M
51-6900 was used in immunocytochemistry to describe different steps of in vitro neurodevelopment
Tue Mar 01 00:00:00 UTC 2011
Delayed appearance of the scaffolding proteins PSD-95 and Homer-1 at the developing rat calyx of Held synapse.
The Journal of comparative neurology
Soria Van Hoeve JS,Borst JG
51-6900 was used in immunohistochemistry to study the development of rat calyx of Held synapse
Mon Nov 15 00:00:00 UTC 2010
NMDA receptor subunit NRI and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder.
Schizophrenia research
Toro C,Deakin JF
51-6900 was used in immunohistochemistry - paraffin section and western blot to examine the expression of NR1 and PSD-95 in the hippocampal dentate gyrus and orbitofrontal cortex in patients with schizophrenia and mood disorder
Thu Dec 15 00:00:00 UTC 2005
Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Cepeda C,Hurst RS,Calvert CR,Hernández-Echeagaray E,Nguyen OK,Jocoy E,Christian LJ,Ariano MA,Levine MS
Sat Feb 01 00:00:00 UTC 2003
