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Product Details
PA1-043
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues N(352) K L C D K P A S P R H Y S P(366) of human PSD-93.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2092050
Product Specific Information
PA1-043 detects Post Synaptic Density 93 (PSD-93) from rat and human tissues. This antibody does not detect other synapse-associated protein family members.^M
^M
PA1-043 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, this antibody detects an ~110 kDa protein representing PSD-93 in rat brain extract. Immunohistochemical staining of PSD-93 in rat cerebellum with PA1-043 yields a pattern consistent with post-synaptic localization.^M
^M
The PA1-043 immunogen is a synthetic peptide corresponding to residues N(352) K L C D K P A S P R H Y S P(366) of human PSD-93. This sequence is completely conserved in human PSD-93. PA1-043 immunizing peptide (Cat. # PEP-021) is available for use in neutralization and control experiments.
Target Information
PSD-93, also known as chapsyn-110, is one of a family of plasma membrane-associated proteins found in synaptic junctions. PSD-93 is unique among family members in its expression in Purkinje neuron cell bodies and dendrites. PSD-93 has three ~90 amino acid repeats called PDZ domains, a single interior SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticiyt. PSD-93 is believed to participate in the clustering of certain proteins, including NMDA receptors and shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between PSD-93 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif may interact with PSD-93 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-93 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Channel-associated protein of synapse-110; channel-associated protein of synapses, 110kDa; Chapsyn-1; Chapsyn-110; discs large 2; discs large homolog 2; discs, large homolog 2; discs, large homolog 2, chapsyn-110; Disks large homolog 2; Postsynaptic density protein PSD-93; protein phosphatase 1, regulatory subunit 58; synaptic density protein PSD-93
Gene Aliases: A330103J02Rik; B230218P12Rik; B330007M19Rik; chapsyn-110; DLG2; Dlgh2; Gm1197; PPP1R58; PSD-93; PSD93
UniProt ID: (Human) Q15700, (Mouse) Q91XM9, (Rat) Q63622
Entrez Gene ID: (Human) 1740, (Mouse) 23859, (Rat) 64053
chemical synaptic transmission
nervous system development
negative regulation of phosphatase activity
sensory perception of pain
receptor clustering
establishment or maintenance of epithelial cell apical/basal polarity
GMP metabolic process
GDP metabolic process
receptor localization to synapse
neuronal ion channel clustering
nucleotide phosphorylation
Performance Guarantee
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