Invitrogen

PSEN2 Polyclonal Antibody

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PSEN2 Polyclonal Antibody

Product Details

PA5-96774

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 267-384 of human PSEN2 (NP_0004382)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.65 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808576

Product Specific Information

Positive Samples: A-549, Human placenta, HepG2, HeLa, Mouse liver, Rat liver; Cellular Location: Endoplasmic reticulum membrane, Golgi apparatus membrane, Multi-pass membrane protein

Immunogen sequence: VLCPKGPLRM LVETAQERNE PIFPALIYSS AMVWTVGMAK LDPSSQGALQ LPYDPEMEED SYDSFGEPSY PEVFEPPLTG YPGEELEEEE ERGVKLGLGD FIFYSVLVGK AAATGSGD

Target Information

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AD3LP; AD5; Alzheimer disease 4; E5-1; Presenilin-2; PS-2; PSEN 2; STM-2

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Gene Aliases: AD3L; AD4; Ad4h; ALG-3; Alg3; CMD1V; PS-2; PS2; PSEN2; PSNL2; STM2

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UniProt ID: (Human) P49810, (Rat) O88777, (Mouse) Q61144

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Entrez Gene ID: (Human) 5664, (Rat) 81751, (Mouse) 19165

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Function(s)
endopeptidase activity aspartic-type endopeptidase activity protein binding molecular_function peptidase activity hydrolase activity aspartic endopeptidase activity, intramembrane cleaving aspartic protease
Process(es)
response to hypoxia membrane protein ectodomain proteolysis calcium ion transport Notch signaling pathway Notch receptor processing protein processing membrane protein intracellular domain proteolysis intracellular signal transduction amyloid precursor protein catabolic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of catalytic activity ephrin receptor signaling pathway beta-amyloid metabolic process negative regulation of transcription from RNA polymerase II promoter cell fate specification somitogenesis positive regulation of receptor recycling negative regulation of protein phosphorylation hair follicle development hematopoietic progenitor cell differentiation T cell activation involved in immune response myeloid leukocyte differentiation proteolysis negative regulation of epidermal growth factor-activated receptor activity regulation of epidermal growth factor-activated receptor activity learning or memory memory protein transport dorsal/ventral neural tube patterning embryonic limb morphogenesis forebrain development negative regulation of protein complex assembly negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process endoplasmic reticulum calcium ion homeostasis locomotion regulation of protein binding skin morphogenesis cellular protein metabolic process regulation of synaptic plasticity lung alveolus development thymus development brain morphogenesis positive regulation of coagulation T cell receptor signaling pathway negative regulation of ubiquitin-protein transferase activity protein maturation cardiac muscle contraction negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of apoptotic signaling pathway embryo development anagen
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