Sequence of this protein is as follows: NMLKGQHEKE AADRKRKQEE QMETEQQNKD EGKKPEVKKV EKKRETSMDS RLQRIHAEIK NSLKIDNLDV NRCIEALDEL ASLQVTMQQA QKHTEMITTL KKIRRFKVSQ VIMEKSTMLY NKFKNMFLVG EGDSVITQVL NKSLAEQRQH EEANKTKDQG KKGPNKKLEK EQTGSKTLNG GSDAQDGNQP QHNGESNEDS KDNHEASTKK KPSSEERETE ISLKDSTLDN
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CLL-associated antigen KW-7; dense fine speckles 70; Dense fine speckles 70 kDa protein; DFS 70; Lens epithelium-derived growth factor; mLEDGF; PC4 and SFRS1 interacting protein 2; PC4 and SFRS1-interacting protein; supercoiled DNA binding protein 75; transcriptional coactivator p52/p75; Transcriptional coactivator p75/p52
Gene Aliases: AA408851; AU015605; DFS70; LEDGF; Ledgfa; Ledgfb; p52; p75; PAIP; PSIP1; PSIP2; SBP75