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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
Immunocytochemistry (ICC/IF) |
1:20-1:200 | View 1 publication 1 publication |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Mollusc |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
PSMA6 Fusion Protein Ag2154 (1-246 aa encoded by BC023659) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.17 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MSRGSSAGF DRHITIFSPE GRLYQVEYAF KAINQGGLTS VAVRGKDCAV IVTQKKVPDK LLDSSTVTHL FKITENIGCV MTGMTADSRS QVQRARYEAA NWKYKYGYEI PVDMLCKRIA DISQVYTQNA EMRPLGCCMI LIGIDEEQGP QVYKCDPAGY YCGFKATAAG VKQTESTSFL EKKVKKKFDW TFEQTVETAI TCLSTVLSID FKPSEIEVGV VTVENPKFRI LTEAEIDAHL VALAERD (1-246 aa encoded by BC023659)
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 27 kDa prosomal protein; Macropain iota chain; macropain subunit iota; MGC22756; MGC2333; MGC23846; Multicatalytic endopeptidase complex iota chain; PROS 27; PROS-27; prosomal P27K protein; proteasome (prosome, macropain) subunit, alpha type, 6; proteasome alpha 6 subunit; Proteasome iota chain; Proteasome subunit alpha type-6; proteasome subunit iota; PSA6; PSMA 6; testicular secretory protein Li 44
Gene Aliases: IOTA; p27K; PROS27; PSMA6
UniProt ID: (Human) P60900, (Mouse) Q9QUM9, (Rat) P60901
Entrez Gene ID: (Human) 5687, (Mouse) 26443, (Rat) 29673
Molecular Function:
protease
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