This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit.
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Protein Aliases: proteasome (prosome, macropain) subunit, alpha type, 8; proteasome alpha 8 subunit; proteasome subunit alpha 8; proteasome subunit alpha type 7-like protein variant 1; proteasome subunit alpha type-7-like; Proteasome subunit alpha-type 7-like; Proteasome subunit alpha-type 8; PSMA7L
Gene Aliases: 2410072D24Rik; psma7; PSMA7L; PSMA8; RGD1311659; wu:fk28c01; zgc:77139