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Proteintech
PSMB8 Polyclonal Antibody, CoraLite® 594
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Product Details
CL594-14859
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PSMB8 fusion protein Ag6660
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MLIGTPTPR DTTPSSWLTS SLLVEAAPLD DTTLPTPVSS GCPGLEPTEF FQSLGGDGER NVQIEMAHGT TTLAFKFQHG VIAAVDSRAS AGSYISALRV NKVIEINPYL LGTMSGCAAD CQYWERLLAK ECRLYYLRNG ERISVSAASK LLSNMMCQYR GMGLSMGSMI CGWDKKGPGL YYVDEHGTRL SGNMFSTGSG NTYAYGVMDS GYRPNLSPEE AYDLGRRAIA YATHRDSYSG GVVNMYHMKE DGWVKVESTD VSDLLHQYRE ANQ
Target Information
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAAP-57C1.3; large multifunctional protease 7; Low molecular mass protein 7; low molecular weight protein 7; Macropain subunit C13; MC13 (LMP7); MGC1491; Multicatalytic endopeptidase complex subunit C13; OTTHUMP00000029420; OTTHUMP00000029421; OTTHUMP00000062981; protease component C13; proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7); proteasome catalytic subunit 3i; Proteasome component C13; proteasome subunit beta 5i; proteasome subunit beta type 8; Proteasome subunit beta type-8; Proteasome subunit beta-5i; proteasome subunit MC13; proteasome subunit Y2; proteasome-related gene 7; proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteosome beta 8 subunit; Really interesting new gene 10 protein
Gene Aliases: ALDD; D6S216; D6S216E; JMP; Lmp-7; LMP7; Mc13; NKJO; PSMB5i; PSMB8; RING10; Y2
UniProt ID: (Human) P28062, (Mouse) P28063
Entrez Gene ID: (Human) 5696, (Mouse) 16913
MAPK cascade
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of cellular amino acid metabolic process
viral process
anaphase-promoting complex-dependent catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of mRNA stability
fat cell differentiation
T cell receptor signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of endopeptidase activity
Wnt signaling pathway, planar cell polarity pathway
type I interferon signaling pathway
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
immune system process
proteolysis
proteasomal ubiquitin-independent protein catabolic process
antigen processing and presentation
cell differentiation
proteolysis involved in cellular protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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