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Product Details
PA5-51137
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fusion protein of human PSMD10
Conjugate
Form
Liquid
Concentration
2.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2636585
Product Specific Information
The antibody detects endogenous levels of total PSMD10 protein.
Target Information
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; ankyrin repeat protein; Gankyrin; hepatocellular carcinoma-associated protein p28-II; p28(GANK); proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Gene Aliases: dJ889N15.2; p28; p28(GANK); PSMD10
UniProt ID: (Human) Q8IZK9
Entrez Gene ID: (Human) 5716
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of cellular amino acid metabolic process
apoptotic process
cytoplasmic sequestering of NF-kappaB
positive regulation of cell growth
anaphase-promoting complex-dependent catabolic process
positive regulation of protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of MAPK cascade
regulation of mRNA stability
negative regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of cyclin-dependent protein serine/threonine kinase activity
T cell receptor signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
proteasome regulatory particle assembly
negative regulation of canonical Wnt signaling pathway
negative regulation of release of cytochrome c from mitochondria
positive regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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