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FIGURE: 1 / 1
Positive test controls include: NCI-H460, 293T, Mouse brain, Rat testis. The target is usually found in the following locations: Cytoplasm, Nucleus, cytosol.
Immunogen sequence: YMLLCKIMLN TPEDVQALVS GKLALRYAGR QTEALKCVAQ ASKNRSLADF EKALTDYRAE LRDDPIISTH LAKLYDNLLE QNLIRVIEPF SRVQIEHISS LIKLSKADVE RKLSQMILDK KFHGILDQGE GVLIIFDEPP VDKTYEAALE TIQNMSKVVD SLYNKAKKLT
The 26S proteasome (PSMD11) is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The protein is a non-ATPase subunit of the 19S regulator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit 9; 26S proteasome regulatory subunit p44.5; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
Gene Aliases: 1700089D09Rik; 1810019E17Rik; 2610024G20Rik; 2810055C24Rik; C78232; P44.5; PSMD11; Rpn6; S9
UniProt ID: (Human) O00231, (Mouse) Q8BG32
Entrez Gene ID: (Human) 5717, (Rat) 303353, (Mouse) 69077
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