Immunogen sequence: AAVVEFQRAQS LLSTDREASI DILHSIVKRD IQENDEEAVQ VKEQSILELG SLLAKTGQAA ELGGLLKY
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
The 26S proteasome (PSMD11) is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The protein is a non-ATPase subunit of the 19S regulator.
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Protein Aliases: 26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit 9; 26S proteasome regulatory subunit p44.5; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; p44.5; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11; Rpn6; S9
Gene Aliases: p44.5; PSMD11; Rpn6; S9
UniProt ID: (Human) O00231
Entrez Gene ID: (Human) 5717