This target displays homology in the following species: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93%; Zebrafish: 85%
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.
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Protein Aliases: 26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit p55; 26S proteasome regulatory subunit RPN5; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12; proteasome 26S non-ATPase subunit 12; proteasome 26S subunit non-ATPase 12; Rpn5
Gene Aliases: 1500002F15Rik; AI480719; BOS_19371; fc34f08; P55; PSMD12; Rpn5; wu:fb38a06; wu:fc34f08; wu:fc49f02
Molecular Function: enzyme modulator