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Invitrogen
PSMD14 Polyclonal Antibody
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Product Details
PA5149703
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PSMD14
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AVDTAEQVYI SSLALLKMLK HGRAGVPMEV MGLMLGEFVD DYTVRVIDVF AMPQSGTGVS VEAVDPVFQA KMLDMLKQTG RPEMVVGWYH SHPGFGCWLS GVDINTQQSF EALSERAVAV VVDPIQSVKG KVVIDA
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
The 26S proteasome is responsible for most intracellular proteolysis in eukaryotes. POH1 (also known as Rpn11 in yeast) subunit of the 19S complex is responsible for substrate deubiquitination during proteasomal degradation. POH1 appears to be a Zn21-dependent protease, unlike all other known deubiquitinating enzymes (DUBs) that are cysteine proteases. POH1 was first identified as the human functional homolog of the S. pombe pad1 gene, which confers moderate resistance to chemotherapeutic drugs, and also to ultraviolet light when transiently overproduced in mammalian cells. Poh1-induced drug resistance is mediated through AP-1 transcription factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 26S proteasome non-ATPase regulatory subunit 14; 26S proteasome non-ATPase subunit; 26S proteasome regulatory subunit RPN11; 26S proteasome-associated pad1 homolog; 26S proteasome-associated PAD1 homolog 1; MAD1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; proteasome 26S subunit, non-ATPase 14; testis tissue sperm-binding protein Li 69n; Ubiquitin C-terminal hydrolase PSMD14; unnamed protein product
Gene Aliases: 2610312C03Rik; 3200001M20Rik; AA986732; PAD1; POH1; PSMD14; rpm11; RPN11
UniProt ID: (Human) O00487, (Mouse) O35593
Entrez Gene ID: (Human) 10213, (Rat) 311078, (Mouse) 59029
protein binding
peptidase activity
metallopeptidase activity
hydrolase activity
metal ion binding
endopeptidase activator activity
Lys63-specific deubiquitinase activity
proteasome binding
metal-dependent deubiquitinase activity
molecular_function
endopeptidase activity
pyroglutamyl-peptidase activity
translation initiation factor
double-strand break repair via homologous recombination
DNA repair
double-strand break repair via nonhomologous end joining
proteolysis
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
protein deubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
response to ethanol
regulation of proteasomal protein catabolic process
protein K63-linked deubiquitination
positive regulation of endopeptidase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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