Recommended positive controls: A549, HeLa, HepG2, HCT116.
Predicted reactivity: Mouse (98%), Rat (96%), Xenopus laevis (90%), Dog (98%), Pig (100%), Rabbit (95%), Chicken (95%), Sheep (100%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and thus it represses the translation of host-cell, but not HIV-1, mRNAs. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; AF; angiocidin; Antisecretory factor 1; Multiubiquitin chain-binding protein; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; RP11-126K1.1; S5a/antisecretory factor protein
Gene Aliases: AF; AF-1; ASF; MCB1; PSMD4; pUB-R5; Rpn10; S5A
UniProt ID: (Human) P55036
Entrez Gene ID: (Human) 5710
Molecular Function: enzyme modulator