This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: NRVAEFHTEL ERLPAKDIQT NVYIKHPVSL EQYLMEGSYN KVFLAKGNIP AESYTFFIDI LLDTIRDEIA GCIEKAYEKI LFTEATRILF FNTPKKMTDY AKKRGWVLGP NNYYSFASQQ QKPEDTTIPS TELAKQVIEY ARQ
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 97%.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 26S proteasome non-ATPase regulatory subunit 8; 26S proteasome regulatory subunit p31; 26S proteasome regulatory subunit RPN12; 26S proteasome regulatory subunit S14; epididymis secretory sperm binding protein Li 91n; HIP6; HYPF; Nin1p; p31; proteasome (prosome, macropain) 26S subunit, non-ATPase, 8; proteasome 26S non-ATPase subunit 8; proteasome 26S subunit, non-ATPase, 8; Rpn12
Gene Aliases: 6720456J22Rik; AA407360; AL033291; AL033322; AL033323; C76433; HEL-S-91n; HIP6; HYPF; Nin1p; p31; PSMD8; Rpn12; S14
Molecular Function: enzyme modulator