This antibody is expected to cross-react with rat, chicken, and human due to 100% sequence homology.
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
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Protein Aliases: mesenchymal dysplasia; Patched; Patched 1; Protein patched homolog 1; PTC; PTC1; Ptch1 protein +12b
Gene Aliases: A230106A15Rik; mes; Ptc; Ptc1; Ptch; Ptch1
UniProt ID: (Mouse) Q61115
Entrez Gene ID: (Mouse) 19206
Molecular Function: receptor