Invitrogen

PTCH Polyclonal Antibody

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PTCH Polyclonal Antibody

Product Details

PA1-23381

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide-amino acids 269-279 of Mouse PTCH1.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2253264

Product Specific Information

This antibody is expected to cross-react with rat, chicken, and human due to 100% sequence homology.

Target Information

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: etID309849.2; FLJ26746; FLJ42602; HGNC:9585; mesenchymal dysplasia; OTTHUMP00000021709; OTTHUMP00000021710; patched; Patched 1; patched1; Protein patched homolog 1; PTC; ptc-1; PTCH protein -3; Ptch1 protein +12b; RP11-435O5.3

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Gene Aliases: A230106A15Rik; mes; Ptc; Ptc1; Ptch; Ptch1

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UniProt ID: (Mouse) Q61115

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Entrez Gene ID: (Mouse) 19206

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Function(s)
patched binding smoothened binding protein binding hedgehog receptor activity heparin binding zinc ion binding cholesterol binding cyclin binding protein complex binding hedgehog family protein binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter branching involved in ureteric bud morphogenesis in utero embryonic development cell fate determination neural tube formation neural tube closure heart morphogenesis signal transduction smoothened signaling pathway regulation of mitotic cell cycle pattern specification process brain development negative regulation of cell proliferation epidermis development regulation of smoothened signaling pathway organ morphogenesis dorsal/ventral pattern formation epidermal cell fate specification response to chlorate positive regulation of cholesterol efflux protein processing spinal cord motor neuron differentiation neural tube patterning dorsal/ventral neural tube patterning neural plate axis specification embryonic limb morphogenesis mammary gland development regulation of protein localization limb morphogenesis hindlimb morphogenesis regulation of growth negative regulation of multicellular organism growth regulation of cell proliferation glucose homeostasis negative regulation of sequence-specific DNA binding transcription factor activity keratinocyte proliferation positive regulation of epidermal cell differentiation negative regulation of osteoblast differentiation negative regulation of smoothened signaling pathway embryonic organ development negative regulation of epithelial cell proliferation negative regulation of cell division pharyngeal system development mammary gland duct morphogenesis mammary gland epithelial cell differentiation smoothened signaling pathway involved in dorsal/ventral neural tube patterning cell differentiation involved in kidney development somite development cellular response to cholesterol cell proliferation involved in metanephros development protein targeting to plasma membrane
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