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Invitrogen

PTEN Polyclonal Antibody

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PTEN Polyclonal Antibody

Product Details

PA5-15540

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunocytochemistry (ICC/IF)

1:10-1:50
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 371-403 amino acids from the C-terminal region of human PTEN
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Amount

800 µg

Purification

Ammonium sulfate precipitation, Size-exclusion - Dialysis

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2174181

Target Information

PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. PTEN plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Also, PTEN may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induces less tumor suppressive ability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Inositol polyphosphate 3-phosphatase; mitochondrial phosphatase and tensin protein alpha; mitochondrial PTENalpha; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; Mutated in multiple advanced cancers 1; N-terminal extended PTEN isoform; uses an alternative ATT initiation codon in PTEN 5'UTR; phosphatidylinositol-3,4,5-trisphosphate3-phosphatase; phosphatase and tensin; Phosphatase and tensin homolog; phosphatase and tensin-like protein; phosphatidylinositol 3; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 5; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 6; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 7; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, isoform 21; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, isoform 22; phosphatidylinositol-3; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase; protein tyrosine phosphatase and tensin homolog; PTEN; pten tumor suppressor; PTEN variant PTEN-K267Rfs*9; PTEN variant PTEN-L247*; PTEN variant PTEN-R234Afs*11; PTENepsilon; TEP1; unnamed protein product

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Gene Aliases: 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN; PTEN1; PTENbeta; PTENgama; TEP1

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UniProt ID: (Human) P60484

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Entrez Gene ID: (Human) 5728

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Function(s)
phosphatidylinositol-3-phosphatase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein binding beta-catenin binding lipid binding anaphase-promoting complex binding phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity hydrolase activity phosphatase activity enzyme binding PDZ domain binding inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity identical protein binding inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity phosphatidylinositol phosphate phosphatase activity molecular function inhibitor activity ubiquitin-specific protease binding ubiquitin ligase activator activity
Process(es)
osteoblast differentiation protein dephosphorylation lipid metabolic process phosphatidylinositol biosynthetic process apoptotic process spindle assembly involved in female meiosis neuron-neuron synaptic transmission nervous system development synapse assembly central nervous system development heart development learning or memory locomotory behavior positive regulation of cell proliferation negative regulation of cell proliferation regulation of signal transduction positive regulation of macromolecule metabolic process negative regulation of cell communication negative regulation of epithelial to mesenchymal transition regulation of neuron projection development negative regulation of neuron projection development cell migration dentate gyrus development central nervous system neuron axonogenesis negative regulation of signaling negative regulation of cell migration adult behavior regulation of protein stability central nervous system myelin maintenance negative regulation of peptidyl-serine phosphorylation multicellular organismal response to stress social behavior maternal behavior protein kinase B signaling locomotor rhythm regulation of cell differentiation negative regulation of osteoblast differentiation negative regulation of cell size positive regulation of transcription from RNA polymerase II promoter negative regulation of organ growth phosphatidylinositol dephosphorylation forebrain morphogenesis cell motility negative regulation of axonogenesis protein stabilization negative regulation of developmental process negative regulation of cellular component organization negative regulation of multicellular organismal process negative regulation of keratinocyte migration regulation of cell cycle negative regulation of focal adhesion assembly regulation of protein kinase B signaling negative regulation of protein kinase B signaling rhythmic synaptic transmission synapse maturation prepulse inhibition dendritic spine morphogenesis regulation of biological quality cellular response to electrical stimulus negative regulation of excitatory postsynaptic potential presynaptic membrane assembly postsynaptic density assembly positive regulation of intracellular signal transduction negative regulation of cell cycle G1/S phase transition negative regulation of wound healing, spreading of epidermal cells negative regulation of vascular smooth muscle cell proliferation positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of G1/S transition of mitotic cell cycle positive regulation of excitatory postsynaptic potential negative regulation of cellular senescence negative regulation of synaptic vesicle clustering
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