Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%) Monkey (90%) Marmoset (85%).
The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses.
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Protein Aliases: AS1; ASRT1; Dp prostanoid receptor; Dp receptor; PGD receptor; PGD2 receptor; Prostaglandin D2 receptor; Prostaglandin D2 receptor (DP); Prostaglandin DP receptor; Prostanoid DP receptor; PTGDR; PTGDR1
Gene Aliases: AS1; ASRT1; DP; DP1; PTGDR; PTGDR1
UniProt ID: (Human) Q13258
Entrez Gene ID: (Human) 5729