|Western Blot (WB)||2 µg/ml|
|Tested Species reactivity||Bovine, Dog, Cat, Human, Mouse, Non-human primate, Rabbit, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide made to a region within residues 120-190 of the human PTGDS protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 30% glycerol|
|Contains||0.1% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody has 89% sequence homology with equine, 85% with sheep, and 82% with porcine samples.
Suggested positive control: antigen standard for PTGDS (transient overexpression lysate), human brain protein.
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer and quote;s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Beta-trace protein; Cerebrin-28; Glutathione S-transferase; glutathione S-transferase sigma; Glutathione-dependent PGD synthase; glutathione-dependent PGD synthetase; Glutathione-independent PGD synthase; Glutathione-independent PGD synthetase; Glutathione-requiring prostaglandin D synthase; GST class-sigma; H-PGDS; Hematopoietic prostaglandin D synthase; hematopoietic prostaglandin D2 synthase; L-PGDS; lipocalin-type prostaglandin D synthase; Lipocalin-type prostaglandin-D synthase; PGD2 synthase; PGDS; PGDS2; Prostaglandin D synthase; prostaglandin D2 synthase (21 kDa, brain); prostaglandin D2 synthase 2, hematopoietic; prostaglandin D2 synthase 21kDa (brain); prostaglandin D2 synthase, hematopoietic; Prostaglandin-; Prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase; testis tissue sperm-binding protein Li 63n
Gene Aliases: 21kDa; BOS_12255; GSTS; GSTS1; GSTS1-1; H-PGDS; HPGDS; L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2; PH2DISO; PTGDS; PTGDS2; Ptgs3
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.