Immunogen sequence: SWLREKKAAL SMCKSVVAPA TDGGLNLTST FLRKNQCETR TMLLQPAGSL GSYSYRSPHW GSTYSVSVVE TDYDQYALLY SQGSKGPGED FRMATLYSRT QT
Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 74%.
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer's disease.
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Protein Aliases: Beta-trace protein; Cerebrin-28; Glutathione-independent PGD synthase; glutathione-independent PGD synthetase; L-PGDS; lipocalin-type prostaglandin D synthase; Lipocalin-type prostaglandin-D synthase; PGD2 synthase; prostaglandin D synthase; prostaglandin D2 synthase 21kDa (brain); Prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase; testis tissue sperm-binding protein Li 63n
Gene Aliases: L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2; PTGDS
UniProt ID: (Human) P41222
Entrez Gene ID: (Human) 5730
Molecular Function: transfer/carrier protein