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Invitrogen
PTGDS Polyclonal Antibody
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FIGURE: 1 / 1
PTGDS Antibody (PA5-95977) in WB
Western blot analysis of PTGDS in extracts of Mouse heart. Samples were incubated with PTGDS Polyclonal antibody (Product # PA5-95977) using a dilution of 1:500, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
PA5-95977
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 23-190 of human PTGDS (NP_0009453)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: APEAQVSVQP NFQQDKFLGR WFSAGLASNS SWLREKKAAL SMCKSVVAPA TDGGLNLTST FLRKNQCETR TMLLQPAGSL GSYSYRSPHW GSTYSVSVVE TDYDQYALLY SQGSKGPGED FRMATLYSRT QTPRAELKEK FTAFCKAQGF TEDTIVFLPQ TDKCMTEQ; Positive Samples: Mouse heart; Cellular Location: Cytoplasm, Golgi apparatus, Nucleus membrane, Rough endoplasmic reticulum, perinuclear region
Target Information
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beta-trace protein; Cerebrin-28; Glutathione-independent PGD synthase; glutathione-independent PGD synthetase; L-PGDS; lipocalin-type prostaglandin D synthase; Lipocalin-type prostaglandin-D synthase; PGD2 synthase; PGDS; PGDS2; Prostaglandin D synthase; prostaglandin D2 synthase (21 kDa, brain); prostaglandin D2 synthase 21kDa (brain); Prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase; testis tissue sperm-binding protein Li 63n
Gene Aliases: 21kDa; L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2; PH2DISO; PTGDS; Ptgs3
UniProt ID: (Human) P41222, (Mouse) O09114, (Rat) P22057
Entrez Gene ID: (Human) 5730, (Mouse) 19215, (Rat) 25526
prostaglandin biosynthetic process
transport
cyclooxygenase pathway
regulation of circadian sleep/wake cycle, sleep
response to glucocorticoid
negative regulation of male germ cell proliferation
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
prostaglandin metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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