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PA1-20764 detects Prostaglandin E Receptor EP4 in Human samples.
PA1-20764 has been successfully used in Immunocytochemistry and Immunohistochemistry (Paraffin) procedures.
PA1-20764 immunogen corresponds to Synthetic peptide conjugated to KLH (aa sequence is considered to be commercially sensitive)..
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2. This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1, regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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