This target displays homology in the following species: Cow: 92%; Dog: 100%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 93%; Sheep: 92%
The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: FP prostanoid receptor; FP receptor; PGF receptor; PGF2 alpha receptor; PGF2-alpha receptor; Prostaglandin F receptor; Prostaglandin F receptor (FP); prostaglandin F2 alpha receptor; Prostaglandin F2-alpha receptor; prostaglandin F2alpha receptor; prostaglandin receptor (2-alpha); Prostanoid FP receptor; PTGFR
Gene Aliases: AI957154; BOS_3355; FP; PF2AR; PGF; PTGFR