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PTGIS Antibody (PA5-53132) in WB
Western blot analysis of PTGIS in control (vector only transfected HEK293T lysate) and PTGIS over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells). Samples were probed using a PTGIS Polyclonal Antibody (Product # PA5-53132).
Product Details
PA5-53132
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PTGIS. Recombinant protein control fragment (Product #RP-90174).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2646110
Product Specific Information
Immunogen sequence: LTLYGIEALP RTHESQAQDR VHSADVFHTF RQLDRLLPKL ARGSLSVGDK DHMCSVKSRL WKLLSPARLA RRAHRSKWLE SYLLHLEEMG VSEEMQARAL VLQLWATQGN MGPAAFWLLL FLLKNPEALA AVRGELESIL WQAEQ
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 85%.
Target Information
CYP8A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cytochrome P450, family 8, subfamily A, polypeptide 1; Hydroperoxy icosatetraenoate dehydratase; MGC126858; MGC126860; Prostacyclin synthase; Prostaglandin I2 synthase
Gene Aliases: CYP8; CYP8A1; PGIS; PTGI; PTGIS
UniProt ID: (Human) Q16647
Entrez Gene ID: (Human) 5740
prostaglandin biosynthetic process
icosanoid metabolic process
nicotinamide metabolic process
embryo implantation
cyclooxygenase pathway
negative regulation of NF-kappaB transcription factor activity
positive regulation of peroxisome proliferator activated receptor signaling pathway
negative regulation of nitric oxide biosynthetic process
positive regulation of angiogenesis
decidualization
negative regulation of inflammatory response
oxidation-reduction process
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to hypoxia
apoptotic signaling pathway
positive regulation of execution phase of apoptosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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