Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MIVQRVVLN SRPGKNGNPV AENFRMEEVY LPDNINEGQV QVRTLYLSVD PYMRCRMNED TGTDYITPWQ LSQVVDGGGI GIIEESKHTN LTKGDFVTSF YWPWQTKVIL DGNSLEKVDP QLVDGHLSYF LGAIGMPGLT SLIGIQEKGH ITAGSNKTMV VSGAAGACGS VAGQIGHFLG CSRVVGICGT HEKCILLTSE LGFDAAINYK KDNVAEQLRE SCPAGVDVYF DNVGGNISDT VISQMNENSH IILCGQISQY NKDVPYPPPL SPAIEAIQKE RNITRERFLV LNYKDKFEPG ILQLSQWFKE GKLKIKETVI NGLENMGAAF QSMMTGGNIG KQIVCISEEI SL (1-351 aa encoded by BC059364)
ZADH1 (zinc binding alcohol dehydrogenase, domain containing 1), also known as PTGR2 (prostaglandin reductase 2), PGR2 or 15-oxoprostaglandin 13-reductase, is a 351 amino acid cytoplasmic protein that belongs to the NADP-dependent oxidoreductase L4BD family. Functioning as s a 15-oxoprostaglandin 13-reductase, ZADH1 catalyzes the conversion of 15-keto-prostaglandin E2 to 15-keto-13, 14-dihydro-prostaglandin E2 in a NADPH-dependent manner. ZADH1 overexpression has been found to repress PPAR gamma transcriptional activity and adipocyte differentiation. Widely expressed, ZADH1 is found at highest levels in heart, kidney, liver, pancreas and prostate, with moderate levels found in brain, small intestine, lung, testis and skeletal muscle. ZADH1 exists as a monomer, utilizes NADPH as a cofactor, and undergoes alternative splicing to produce two isoforms that are encoded by a gene located on human chromosome 14q24.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 15-oxoprostaglandin 13-reductase; 15-oxoprostaglandin 13-reductase {ECO:0000250|UniProtKB:Q8VDQ1}; 15-oxoprostaglandin-delta13-reductase; epididymis secretory protein Li 298; PRG-2; PRG-2 {ECO:0000250|UniProtKB:Q8VDQ1}; PRG2; Prostaglandin reductase 2; prostaglandin reductase 2 {ECO:0000250|UniProtKB:Q8VDQ1}; ptgr2 {ECO:0000250|UniProtKB:Q8VDQ1}; zinc binding alcohol dehydrogenase, domain containing 1; Zinc-binding alcohol dehydrogenase domain-containing protein 1
Gene Aliases: 1810016I24Rik; 9130222H03Rik; 9630002F03Rik; AI838763; B830026H24Rik; HEL-S-298; PGR-2; PGR2; PRG-2; PTGR2; ZADH1
UniProt ID: (Human) Q8N8N7, (Rat) Q5BK81, (Mouse) Q8VDQ1
Entrez Gene ID: (Human) 145482, (Rat) 299194, (Mouse) 77219
Molecular Function: reductase
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