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Invitrogen
PTGR2 Polyclonal Antibody
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FIGURE: 1 / 5
PTGR2 Antibody (PA5-101972) in IHC (P)
Immunohistochemistry analysis of PTGR2 in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PTGR2 polyclonal antibody (Product # PA5-101972) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-101972
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PTGR2(Accession Q8N8N7), corresponding to amino acid residues I186-I236.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ZADH1.
Target Information
ZADH1 (zinc binding alcohol dehydrogenase, domain containing 1), also known as PTGR2 (prostaglandin reductase 2), PGR2 or 15-oxoprostaglandin 13-reductase, is a 351 amino acid cytoplasmic protein that belongs to the NADP-dependent oxidoreductase L4BD family. Functioning as s a 15-oxoprostaglandin 13-reductase, ZADH1 catalyzes the conversion of 15-keto-prostaglandin E2 to 15-keto-13, 14-dihydro-prostaglandin E2 in a NADPH-dependent manner. ZADH1 overexpression has been found to repress PPAR gamma transcriptional activity and adipocyte differentiation. Widely expressed, ZADH1 is found at highest levels in heart, kidney, liver, pancreas and prostate, with moderate levels found in brain, small intestine, lung, testis and skeletal muscle. ZADH1 exists as a monomer, utilizes NADPH as a cofactor, and undergoes alternative splicing to produce two isoforms that are encoded by a gene located on human chromosome 14q24.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 15-oxoprostaglandin 13-reductase; 15-oxoprostaglandin 13-reductase {ECO:0000250|UniProtKB:Q8VDQ1}; 15-oxoprostaglandin-delta13-reductase; epididymis secretory protein Li 298; PRG-2; PRG-2 {ECO:0000250|UniProtKB:Q8VDQ1}; PRG2; Prostaglandin reductase 2; prostaglandin reductase 2 {ECO:0000250|UniProtKB:Q8VDQ1}; ptgr2 {ECO:0000250|UniProtKB:Q8VDQ1}; zinc binding alcohol dehydrogenase, domain containing 1; Zinc-binding alcohol dehydrogenase domain-containing protein 1
Gene Aliases: HEL-S-298; PGR2; PTGR2; ZADH1
UniProt ID: (Human) Q8N8N7, (Rat) Q5BK81
Entrez Gene ID: (Human) 145482, (Rat) 299194
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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