Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: VAGKIGHFLG CSRVVGICGT HEKCILLTSE LGFDAAINYK KDNVAEQLRE SCPAGVDVYF DNVGGNISDT VISQMNENSH IILCGQISQY NKDVPYPPPL SPAIEAIQKE RNITRERFLV LNYKDKFEPG ILQLSQWFKE
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 87%.
ZADH1 (zinc binding alcohol dehydrogenase, domain containing 1), also known as PTGR2 (prostaglandin reductase 2), PGR2 or 15-oxoprostaglandin 13-reductase, is a 351 amino acid cytoplasmic protein that belongs to the NADP-dependent oxidoreductase L4BD family. Functioning as s a 15-oxoprostaglandin 13-reductase, ZADH1 catalyzes the conversion of 15-keto-prostaglandin E2 to 15-keto-13, 14-dihydro-prostaglandin E2 in a NADPH-dependent manner. ZADH1 overexpression has been found to repress PPAR gamma transcriptional activity and adipocyte differentiation. Widely expressed, ZADH1 is found at highest levels in heart, kidney, liver, pancreas and prostate, with moderate levels found in brain, small intestine, lung, testis and skeletal muscle. ZADH1 exists as a monomer, utilizes NADPH as a cofactor, and undergoes alternative splicing to produce two isoforms that are encoded by a gene located on human chromosome 14q24.3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 15-oxoprostaglandin 13-reductase; 15-oxoprostaglandin-delta13-reductase; epididymis secretory protein Li 298; PRG-2; PRG2; Prostaglandin reductase 2; zinc binding alcohol dehydrogenase, domain containing 1; Zinc-binding alcohol dehydrogenase domain-containing protein 1
Gene Aliases: HEL-S-298; PGR2; PTGR2; ZADH1
UniProt ID: (Human) Q8N8N7
Entrez Gene ID: (Human) 145482
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support