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Invitrogen
PTH Polyclonal Antibody
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FIGURE: 1 / 2
PTH Antibody (PA5-99181) in ICC/IF
Immunofluorescent analysis of PTH in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and PTH polyclonal antibody (Product # PA5-99181) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-99181
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PTH(Accession P01270), corresponding to amino acid residues L55-D105.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Parathyroid Hormone.
Target Information
This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Parathormone; Parathyrin; Parathyroid hormone; parathyroid hormone 1; prepro-PTH; preproparathyroid hormone; PTH; unnamed protein product
Gene Aliases: FIH1; PTH; PTH1
UniProt ID: (Human) P01270
Entrez Gene ID: (Human) 5741
skeletal system development
transcription from RNA polymerase II promoter
cellular calcium ion homeostasis
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
Rho protein signal transduction
cell-cell signaling
hormone-mediated apoptotic signaling pathway
macromolecule biosynthetic process
response to xenobiotic stimulus
positive regulation of signal transduction
response to lead ion
regulation of gene expression
positive regulation of gene expression
negative regulation of gene expression
magnesium ion homeostasis
bone mineralization
positive regulation of bone mineralization
response to nutrient levels
negative regulation of chondrocyte differentiation
response to vitamin D
bone resorption
response to ethanol
positive regulation of glycogen biosynthetic process
positive regulation of ossification
positive regulation of transcription from RNA polymerase II promoter
cAMP metabolic process
positive regulation of glucose import
response to cadmium ion
homeostasis of number of cells within a tissue
phosphate ion homeostasis
calcium ion homeostasis
positive regulation of inositol phosphate biosynthetic process
response to parathyroid hormone
response to fibroblast growth factor
positive regulation of cell proliferation in bone marrow
negative regulation of apoptotic process in bone marrow
positive regulation of osteoclast proliferation
adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway
negative regulation of bone mineralization involved in bone maturation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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