A suggested positive control is human colon tissue lysate.
PA5-20425 can be used with blocking peptide PEP-0542.
Protein-tyrosine kinases (PTKs) play important roles in regulating cell proliferation and differentiation during development. One member of the PTK family, PTK7, has been suggested to regulate the planar cell polarity (PCP) pathway in vertebrates and may play a role in neural convergent extension and neural tube closure. PTK7 has also been implicated in the development of cancer. Loss of PTK7 expression was seen in several melanoma cell lines and biopsies. Conversely, high-throughput analysis of acute myeloid leukemia samples showed an increased level of PTK7 expression compared to normal bone marrow and purified CD34+ cells. Multiple isoforms of PTK7 are known to exist.
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Protein Aliases: CCK-4; CCK4; Colon carcinoma kinase 4; colon carcinoma kinase-4; Inactive tyrosine-protein kinase 7; Protein chuzhoi; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; PTK7 protein tyrosine kinase 7; receptor tyrosine kinase-like protein; serum response factor; Tyrosine-protein kinase-like 7
Gene Aliases: 8430404F20Rik; CCK-4; CCK4; chz; mPTK7/CCK4; PTK7; Srf